![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC40A1 |
Gene summary for SLC40A1 |
![]() |
Gene information | Species | Human | Gene symbol | SLC40A1 | Gene ID | 30061 |
Gene name | solute carrier family 40 member 1 | |
Gene Alias | FPN1 | |
Cytomap | 2q32.2 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q9NP59 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
30061 | SLC40A1 | GSM4909286 | Human | Breast | IDC | 1.72e-05 | -1.52e-01 | 0.1081 |
30061 | SLC40A1 | GSM4909289 | Human | Breast | IDC | 2.36e-02 | 3.30e-01 | 0.1064 |
30061 | SLC40A1 | GSM4909290 | Human | Breast | IDC | 6.49e-08 | 2.03e-01 | 0.2096 |
30061 | SLC40A1 | GSM4909293 | Human | Breast | IDC | 1.04e-06 | 2.39e-01 | 0.1581 |
30061 | SLC40A1 | GSM4909296 | Human | Breast | IDC | 2.20e-08 | 4.11e-01 | 0.1524 |
30061 | SLC40A1 | GSM4909297 | Human | Breast | IDC | 1.39e-05 | 4.25e-01 | 0.1517 |
30061 | SLC40A1 | GSM4909298 | Human | Breast | IDC | 2.46e-07 | 2.70e-01 | 0.1551 |
30061 | SLC40A1 | GSM4909302 | Human | Breast | IDC | 1.86e-42 | 9.76e-01 | 0.1545 |
30061 | SLC40A1 | GSM4909303 | Human | Breast | IDC | 3.42e-06 | 3.80e-01 | 0.0438 |
30061 | SLC40A1 | GSM4909304 | Human | Breast | IDC | 1.83e-58 | 1.10e+00 | 0.1636 |
30061 | SLC40A1 | GSM4909305 | Human | Breast | IDC | 4.48e-13 | 5.46e-01 | 0.0436 |
30061 | SLC40A1 | GSM4909306 | Human | Breast | IDC | 2.74e-06 | 3.32e-01 | 0.1564 |
30061 | SLC40A1 | GSM4909307 | Human | Breast | IDC | 1.64e-02 | -1.41e-01 | 0.1569 |
30061 | SLC40A1 | GSM4909311 | Human | Breast | IDC | 8.65e-03 | -3.36e-02 | 0.1534 |
30061 | SLC40A1 | GSM4909312 | Human | Breast | IDC | 1.20e-24 | 7.60e-01 | 0.1552 |
30061 | SLC40A1 | GSM4909313 | Human | Breast | IDC | 1.48e-02 | 2.77e-01 | 0.0391 |
30061 | SLC40A1 | GSM4909319 | Human | Breast | IDC | 1.03e-03 | -1.36e-01 | 0.1563 |
30061 | SLC40A1 | M5 | Human | Breast | IDC | 2.20e-03 | 5.00e-01 | 0.1598 |
30061 | SLC40A1 | NCCBC14 | Human | Breast | DCIS | 1.39e-05 | 4.67e-01 | 0.2021 |
30061 | SLC40A1 | NCCBC3 | Human | Breast | DCIS | 5.76e-03 | 3.29e-01 | 0.1198 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005507613 | Breast | IDC | transition metal ion homeostasis | 23/1434 | 138/18723 | 3.20e-04 | 4.79e-03 | 23 |
GO:004691612 | Breast | IDC | cellular transition metal ion homeostasis | 20/1434 | 115/18723 | 4.35e-04 | 5.90e-03 | 20 |
GO:000682611 | Breast | IDC | iron ion transport | 11/1434 | 58/18723 | 4.10e-03 | 3.25e-02 | 11 |
GO:005507212 | Breast | IDC | iron ion homeostasis | 14/1434 | 85/18723 | 4.98e-03 | 3.77e-02 | 14 |
GO:0070839 | Breast | IDC | metal ion export | 10/1434 | 54/18723 | 7.22e-03 | 4.96e-02 | 10 |
GO:005507622 | Breast | DCIS | transition metal ion homeostasis | 23/1390 | 138/18723 | 2.04e-04 | 3.27e-03 | 23 |
GO:004691621 | Breast | DCIS | cellular transition metal ion homeostasis | 20/1390 | 115/18723 | 2.91e-04 | 4.27e-03 | 20 |
GO:000682621 | Breast | DCIS | iron ion transport | 11/1390 | 58/18723 | 3.23e-03 | 2.73e-02 | 11 |
GO:005507221 | Breast | DCIS | iron ion homeostasis | 14/1390 | 85/18723 | 3.78e-03 | 3.03e-02 | 14 |
GO:00708391 | Breast | DCIS | metal ion export | 10/1390 | 54/18723 | 5.83e-03 | 4.18e-02 | 10 |
GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
GO:0046916 | Colorectum | AD | cellular transition metal ion homeostasis | 43/3918 | 115/18723 | 3.62e-05 | 6.56e-04 | 43 |
GO:0055072 | Colorectum | AD | iron ion homeostasis | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0006879 | Colorectum | AD | cellular iron ion homeostasis | 25/3918 | 67/18723 | 1.51e-03 | 1.27e-02 | 25 |
GO:00550762 | Colorectum | MSS | transition metal ion homeostasis | 45/3467 | 138/18723 | 4.99e-05 | 9.02e-04 | 45 |
GO:00550722 | Colorectum | MSS | iron ion homeostasis | 29/3467 | 85/18723 | 4.44e-04 | 5.32e-03 | 29 |
GO:00469162 | Colorectum | MSS | cellular transition metal ion homeostasis | 35/3467 | 115/18723 | 1.33e-03 | 1.26e-02 | 35 |
GO:00068791 | Colorectum | MSS | cellular iron ion homeostasis | 22/3467 | 67/18723 | 3.57e-03 | 2.64e-02 | 22 |
GO:00550764 | Colorectum | FAP | transition metal ion homeostasis | 33/2622 | 138/18723 | 1.22e-03 | 1.14e-02 | 33 |
GO:00550723 | Colorectum | FAP | iron ion homeostasis | 21/2622 | 85/18723 | 5.89e-03 | 3.75e-02 | 21 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0497812 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
hsa0497813 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
hsa0497821 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa0497831 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
hsa04216 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa042161 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa042162 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa042163 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa042164 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042165 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042166 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa042167 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa0421616 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa0421617 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa0421625 | Endometrium | EEC | Ferroptosis | 16/1237 | 41/8465 | 1.09e-04 | 1.08e-03 | 8.08e-04 | 16 |
hsa0421635 | Endometrium | EEC | Ferroptosis | 16/1237 | 41/8465 | 1.09e-04 | 1.08e-03 | 8.08e-04 | 16 |
hsa0421629 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421638 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421621 | Liver | Cirrhotic | Ferroptosis | 23/2530 | 41/8465 | 4.09e-04 | 2.57e-03 | 1.58e-03 | 23 |
hsa0421631 | Liver | Cirrhotic | Ferroptosis | 23/2530 | 41/8465 | 4.09e-04 | 2.57e-03 | 1.58e-03 | 23 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC40A1 | SNV | Missense_Mutation | c.970N>G | p.Phe324Val | p.F324V | Q9NP59 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLC40A1 | SNV | Missense_Mutation | c.593N>G | p.Phe198Cys | p.F198C | Q9NP59 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SLC40A1 | SNV | Missense_Mutation | rs759271778 | c.539T>C | p.Ile180Thr | p.I180T | Q9NP59 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
SLC40A1 | insertion | Frame_Shift_Ins | novel | c.552_555dupCAAC | p.Ile186GlnfsTer56 | p.I186Qfs*56 | Q9NP59 | protein_coding | TCGA-AG-A016-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
SLC40A1 | SNV | Missense_Mutation | novel | c.865N>A | p.Ala289Thr | p.A289T | Q9NP59 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC40A1 | SNV | Missense_Mutation | novel | c.243N>A | p.Asp81Glu | p.D81E | Q9NP59 | protein_coding | deleterious(0.03) | probably_damaging(0.936) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC40A1 | SNV | Missense_Mutation | c.994N>A | p.Ala332Thr | p.A332T | Q9NP59 | protein_coding | deleterious(0.04) | possibly_damaging(0.672) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC40A1 | SNV | Missense_Mutation | novel | c.700N>T | p.Ala234Ser | p.A234S | Q9NP59 | protein_coding | tolerated(0.13) | possibly_damaging(0.796) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC40A1 | SNV | Missense_Mutation | novel | c.243N>A | p.Asp81Glu | p.D81E | Q9NP59 | protein_coding | deleterious(0.03) | probably_damaging(0.936) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC40A1 | SNV | Missense_Mutation | novel | c.467N>A | p.Arg156Lys | p.R156K | Q9NP59 | protein_coding | tolerated(0.36) | possibly_damaging(0.581) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
30061 | SLC40A1 | TRANSPORTER, DRUGGABLE GENOME | Ferroportin mab | 24552640 | ||
30061 | SLC40A1 | TRANSPORTER, DRUGGABLE GENOME | LY2928057 | 22290531 | ||
30061 | SLC40A1 | TRANSPORTER, DRUGGABLE GENOME | antibody | 252166626 |
Page: 1 |