TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZXDB | PVA | Endometrium | ADJ | S100A3,SLC16A6,MECP2, etc. | 3.69e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZXDB | MVA | Endometrium | AEH | S100A3,SLC16A6,MECP2, etc. | 5.34e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
ZXDB | MVA | Endometrium | EEC | S100A3,SLC16A6,MECP2, etc. | 2.68e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_EEC/regulons_activity_in_dotplot.png) |
ZXDB | PVA | Endometrium | Healthy | S100A3,SLC16A6,MECP2, etc. | 2.91e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZXDB | SNV | Missense_Mutation | | c.2374G>C | p.Asp792His | p.D792H | P98169 | protein_coding | deleterious(0) | benign(0.4) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZXDB | SNV | Missense_Mutation | novel | c.1583G>A | p.Arg528His | p.R528H | P98169 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ZXDB | SNV | Missense_Mutation | | c.1609A>G | p.Lys537Glu | p.K537E | P98169 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-A8-A08O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | PD |
ZXDB | SNV | Missense_Mutation | | c.2209N>G | p.Leu737Val | p.L737V | P98169 | protein_coding | tolerated(0.08) | probably_damaging(0.978) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZXDB | SNV | Missense_Mutation | | c.2219C>T | p.Ser740Leu | p.S740L | P98169 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AR-A2LO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZXDB | SNV | Missense_Mutation | novel | c.1495N>A | p.Glu499Lys | p.E499K | P98169 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDB | insertion | Frame_Shift_Ins | novel | c.973_974insT | p.Gln326AlafsTer34 | p.Q326Afs*34 | P98169 | protein_coding | | | TCGA-OK-A5Q2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZXDB | SNV | Missense_Mutation | novel | c.1244N>A | p.Arg415His | p.R415H | P98169 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZXDB | SNV | Missense_Mutation | novel | c.1337N>A | p.Arg446Gln | p.R446Q | P98169 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZXDB | SNV | Missense_Mutation | novel | c.1427N>T | p.Arg476Ile | p.R476I | P98169 | protein_coding | deleterious(0) | possibly_damaging(0.567) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |