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Gene: ZSWIM4 |
Gene summary for ZSWIM4 |
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Gene information | Species | Human | Gene symbol | ZSWIM4 | Gene ID | 65249 |
Gene name | zinc finger SWIM-type containing 4 | |
Gene Alias | ZSWIM4 | |
Cytomap | 19p13.13-p13.12 | |
Gene Type | protein-coding | GO ID | GO:0000151 | UniProtAcc | Q9H7M6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65249 | ZSWIM4 | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.96e-04 | 5.70e-01 | 0.0131 |
65249 | ZSWIM4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.17e-11 | 4.39e-01 | 0.0674 |
65249 | ZSWIM4 | RNA-P17T-P17T-4 | Human | Lung | IAC | 3.66e-05 | 6.43e-01 | 0.343 |
65249 | ZSWIM4 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.01e-03 | 5.40e-01 | 0.3385 |
65249 | ZSWIM4 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.35e-02 | 5.31e-01 | 0.3329 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSWIM4 | SNV | Missense_Mutation | novel | c.2818N>T | p.Gly940Trp | p.G940W | Q9H7M6 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
ZSWIM4 | SNV | Missense_Mutation | c.334G>A | p.Val112Met | p.V112M | Q9H7M6 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZSWIM4 | SNV | Missense_Mutation | c.1963N>A | p.Ala655Thr | p.A655T | Q9H7M6 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZSWIM4 | SNV | Missense_Mutation | c.2891C>T | p.Ser964Leu | p.S964L | Q9H7M6 | protein_coding | deleterious(0.01) | benign(0.039) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZSWIM4 | SNV | Missense_Mutation | rs749160605 | c.1819N>C | p.Thr607Pro | p.T607P | Q9H7M6 | protein_coding | deleterious(0.04) | probably_damaging(0.947) | TCGA-BH-A1F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZSWIM4 | SNV | Missense_Mutation | novel | c.286G>T | p.Ala96Ser | p.A96S | Q9H7M6 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-BH-A42U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZSWIM4 | SNV | Missense_Mutation | novel | c.799N>A | p.Gln267Lys | p.Q267K | Q9H7M6 | protein_coding | tolerated(0.16) | benign(0.201) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZSWIM4 | SNV | Missense_Mutation | c.2786N>T | p.Ser929Leu | p.S929L | Q9H7M6 | protein_coding | deleterious(0) | possibly_damaging(0.653) | TCGA-E2-A14V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ZSWIM4 | SNV | Missense_Mutation | c.1723G>A | p.Glu575Lys | p.E575K | Q9H7M6 | protein_coding | tolerated(0.12) | probably_damaging(0.979) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ZSWIM4 | SNV | Missense_Mutation | novel | c.2503N>A | p.Ala835Thr | p.A835T | Q9H7M6 | protein_coding | tolerated(0.05) | benign(0.175) | TCGA-JL-A3YX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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