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Gene: ZSCAN9 |
Gene summary for ZSCAN9 |
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Gene information | Species | Human | Gene symbol | ZSCAN9 | Gene ID | 7746 |
Gene name | zinc finger and SCAN domain containing 9 | |
Gene Alias | PRD51 | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O15535 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7746 | ZSCAN9 | LZE20T | Human | Esophagus | ESCC | 2.17e-02 | 1.21e-01 | 0.0662 |
7746 | ZSCAN9 | LZE24T | Human | Esophagus | ESCC | 1.05e-03 | 1.14e-01 | 0.0596 |
7746 | ZSCAN9 | P2T-E | Human | Esophagus | ESCC | 7.12e-15 | 1.78e-01 | 0.1177 |
7746 | ZSCAN9 | P4T-E | Human | Esophagus | ESCC | 1.41e-02 | 8.06e-02 | 0.1323 |
7746 | ZSCAN9 | P8T-E | Human | Esophagus | ESCC | 3.56e-12 | 1.60e-01 | 0.0889 |
7746 | ZSCAN9 | P10T-E | Human | Esophagus | ESCC | 6.90e-10 | 1.71e-01 | 0.116 |
7746 | ZSCAN9 | P11T-E | Human | Esophagus | ESCC | 9.90e-04 | 2.45e-01 | 0.1426 |
7746 | ZSCAN9 | P12T-E | Human | Esophagus | ESCC | 2.07e-04 | 1.09e-01 | 0.1122 |
7746 | ZSCAN9 | P15T-E | Human | Esophagus | ESCC | 8.80e-04 | 8.42e-02 | 0.1149 |
7746 | ZSCAN9 | P16T-E | Human | Esophagus | ESCC | 7.90e-03 | 7.67e-02 | 0.1153 |
7746 | ZSCAN9 | P22T-E | Human | Esophagus | ESCC | 2.29e-09 | 8.14e-02 | 0.1236 |
7746 | ZSCAN9 | P23T-E | Human | Esophagus | ESCC | 7.35e-04 | 8.25e-02 | 0.108 |
7746 | ZSCAN9 | P24T-E | Human | Esophagus | ESCC | 4.86e-10 | 7.81e-02 | 0.1287 |
7746 | ZSCAN9 | P26T-E | Human | Esophagus | ESCC | 1.26e-07 | 1.10e-01 | 0.1276 |
7746 | ZSCAN9 | P27T-E | Human | Esophagus | ESCC | 5.69e-08 | 6.91e-02 | 0.1055 |
7746 | ZSCAN9 | P28T-E | Human | Esophagus | ESCC | 1.28e-05 | 7.92e-02 | 0.1149 |
7746 | ZSCAN9 | P30T-E | Human | Esophagus | ESCC | 8.94e-07 | 2.08e-01 | 0.137 |
7746 | ZSCAN9 | P31T-E | Human | Esophagus | ESCC | 8.15e-08 | 6.21e-02 | 0.1251 |
7746 | ZSCAN9 | P36T-E | Human | Esophagus | ESCC | 1.98e-02 | 8.68e-02 | 0.1187 |
7746 | ZSCAN9 | P37T-E | Human | Esophagus | ESCC | 1.27e-07 | 9.24e-02 | 0.1371 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSCAN9 | SNV | Missense_Mutation | c.172C>A | p.Leu58Met | p.L58M | O15535 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
ZSCAN9 | SNV | Missense_Mutation | novel | c.1189A>G | p.Ser397Gly | p.S397G | O15535 | protein_coding | tolerated(0.05) | benign(0.007) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZSCAN9 | SNV | Missense_Mutation | novel | c.762N>T | p.Arg254Ser | p.R254S | O15535 | protein_coding | tolerated(0.33) | benign(0.084) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
ZSCAN9 | insertion | Nonsense_Mutation | novel | c.857_858insATACATTCCAAGACCCCCAGTAGATGCCTGAAACCAAGGGTAATAC | p.Glu287TyrfsTer10 | p.E287Yfs*10 | O15535 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
ZSCAN9 | SNV | Missense_Mutation | rs748143953 | c.35N>A | p.Gly12Asp | p.G12D | O15535 | protein_coding | tolerated(0.32) | benign(0) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZSCAN9 | SNV | Missense_Mutation | novel | c.419A>G | p.Glu140Gly | p.E140G | O15535 | protein_coding | deleterious(0.02) | possibly_damaging(0.619) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ZSCAN9 | SNV | Missense_Mutation | novel | c.1253A>C | p.Gln418Pro | p.Q418P | O15535 | protein_coding | deleterious(0.01) | benign(0.377) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZSCAN9 | SNV | Missense_Mutation | rs775167071 | c.1300N>T | p.Arg434Cys | p.R434C | O15535 | protein_coding | tolerated(0.07) | benign(0.006) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZSCAN9 | SNV | Missense_Mutation | c.124N>T | p.Arg42Cys | p.R42C | O15535 | protein_coding | tolerated(0.1) | benign(0.084) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZSCAN9 | SNV | Missense_Mutation | novel | c.1287N>A | p.His429Gln | p.H429Q | O15535 | protein_coding | tolerated(0.11) | benign(0.106) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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