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Gene: ZSCAN18 |
Gene summary for ZSCAN18 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZSCAN18 | Gene ID | 65982 |
| Gene name | zinc finger and SCAN domain containing 18 | |
| Gene Alias | ZNF447 | |
| Cytomap | 19q13.43 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TBC5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 65982 | ZSCAN18 | LZE20T | Human | Esophagus | ESCC | 9.77e-09 | 2.08e-01 | 0.0662 |
| 65982 | ZSCAN18 | P2T-E | Human | Esophagus | ESCC | 1.27e-28 | 3.79e-01 | 0.1177 |
| 65982 | ZSCAN18 | P8T-E | Human | Esophagus | ESCC | 6.56e-41 | 6.09e-01 | 0.0889 |
| 65982 | ZSCAN18 | P10T-E | Human | Esophagus | ESCC | 3.94e-14 | 2.55e-01 | 0.116 |
| 65982 | ZSCAN18 | P11T-E | Human | Esophagus | ESCC | 3.08e-13 | 5.78e-01 | 0.1426 |
| 65982 | ZSCAN18 | P15T-E | Human | Esophagus | ESCC | 2.90e-08 | 1.89e-01 | 0.1149 |
| 65982 | ZSCAN18 | P16T-E | Human | Esophagus | ESCC | 1.19e-27 | 5.36e-01 | 0.1153 |
| 65982 | ZSCAN18 | P21T-E | Human | Esophagus | ESCC | 2.89e-09 | 1.99e-01 | 0.1617 |
| 65982 | ZSCAN18 | P22T-E | Human | Esophagus | ESCC | 6.05e-26 | 4.55e-01 | 0.1236 |
| 65982 | ZSCAN18 | P24T-E | Human | Esophagus | ESCC | 2.80e-11 | 2.88e-01 | 0.1287 |
| 65982 | ZSCAN18 | P28T-E | Human | Esophagus | ESCC | 3.00e-06 | 1.60e-01 | 0.1149 |
| 65982 | ZSCAN18 | P30T-E | Human | Esophagus | ESCC | 7.90e-07 | 2.03e-01 | 0.137 |
| 65982 | ZSCAN18 | P36T-E | Human | Esophagus | ESCC | 9.59e-05 | 1.84e-01 | 0.1187 |
| 65982 | ZSCAN18 | P38T-E | Human | Esophagus | ESCC | 5.83e-07 | 2.52e-01 | 0.127 |
| 65982 | ZSCAN18 | P39T-E | Human | Esophagus | ESCC | 1.48e-09 | 1.90e-01 | 0.0894 |
| 65982 | ZSCAN18 | P42T-E | Human | Esophagus | ESCC | 2.30e-02 | 1.33e-01 | 0.1175 |
| 65982 | ZSCAN18 | P44T-E | Human | Esophagus | ESCC | 5.20e-07 | 2.04e-01 | 0.1096 |
| 65982 | ZSCAN18 | P47T-E | Human | Esophagus | ESCC | 4.29e-02 | 9.47e-02 | 0.1067 |
| 65982 | ZSCAN18 | P52T-E | Human | Esophagus | ESCC | 4.93e-12 | 3.04e-01 | 0.1555 |
| 65982 | ZSCAN18 | P56T-E | Human | Esophagus | ESCC | 1.33e-02 | 7.47e-01 | 0.1613 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZSCAN18 | SNV | Missense_Mutation | novel | c.1464N>A | p.His488Gln | p.H488Q | Q8TBC5 | protein_coding | tolerated(0.59) | benign(0.017) | TCGA-BH-A18S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZSCAN18 | deletion | Frame_Shift_Del | novel | c.1528delN | p.Leu510TrpfsTer3 | p.L510Wfs*3 | Q8TBC5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| ZSCAN18 | SNV | Missense_Mutation | novel | c.865N>A | p.Asp289Asn | p.D289N | Q8TBC5 | protein_coding | tolerated(0.38) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ZSCAN18 | SNV | Missense_Mutation | c.1321N>A | p.Val441Ile | p.V441I | Q8TBC5 | protein_coding | tolerated(0.34) | benign(0.015) | TCGA-C5-A1BN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| ZSCAN18 | SNV | Missense_Mutation | c.1214N>T | p.Ser405Leu | p.S405L | Q8TBC5 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
| ZSCAN18 | SNV | Missense_Mutation | novel | c.1666N>A | p.Glu556Lys | p.E556K | Q8TBC5 | protein_coding | deleterious_low_confidence(0.02) | benign(0.023) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| ZSCAN18 | SNV | Missense_Mutation | c.176N>A | p.Pro59His | p.P59H | Q8TBC5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-5666-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| ZSCAN18 | SNV | Missense_Mutation | novel | c.506N>G | p.Tyr169Cys | p.Y169C | Q8TBC5 | protein_coding | tolerated(0.19) | probably_damaging(0.985) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZSCAN18 | SNV | Missense_Mutation | c.1591N>T | p.Arg531Trp | p.R531W | Q8TBC5 | protein_coding | deleterious(0.02) | benign(0) | TCGA-AA-3509-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZSCAN18 | SNV | Missense_Mutation | novel | c.866N>C | p.Asp289Ala | p.D289A | Q8TBC5 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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