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Gene: ZP3 |
Gene summary for ZP3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZP3 | Gene ID | 7784 |
| Gene name | zona pellucida glycoprotein 3 | |
| Gene Alias | OOMD3 | |
| Cytomap | 7q11.23 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P21754 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7784 | ZP3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.23e-03 | 3.88e-01 | -0.1207 |
| 7784 | ZP3 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.65e-02 | 2.87e-01 | -0.1464 |
| 7784 | ZP3 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.37e-03 | 2.20e-01 | -0.1001 |
| 7784 | ZP3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.45e-06 | 4.61e-01 | -0.059 |
| 7784 | ZP3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.25e-22 | 9.00e-01 | 0.281 |
| 7784 | ZP3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.79e-02 | 2.27e-01 | 0.3859 |
| 7784 | ZP3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.03e-10 | 4.29e-01 | 0.3005 |
| 7784 | ZP3 | P1T-E | Human | Esophagus | ESCC | 4.71e-02 | 2.83e-01 | 0.0875 |
| 7784 | ZP3 | P2T-E | Human | Esophagus | ESCC | 3.85e-14 | 3.09e-01 | 0.1177 |
| 7784 | ZP3 | P4T-E | Human | Esophagus | ESCC | 9.42e-14 | 3.80e-01 | 0.1323 |
| 7784 | ZP3 | P9T-E | Human | Esophagus | ESCC | 3.62e-11 | 1.63e-01 | 0.1131 |
| 7784 | ZP3 | P10T-E | Human | Esophagus | ESCC | 4.10e-02 | 4.23e-02 | 0.116 |
| 7784 | ZP3 | P11T-E | Human | Esophagus | ESCC | 4.44e-04 | 1.95e-01 | 0.1426 |
| 7784 | ZP3 | P12T-E | Human | Esophagus | ESCC | 3.63e-07 | 1.75e-01 | 0.1122 |
| 7784 | ZP3 | P15T-E | Human | Esophagus | ESCC | 7.73e-26 | 5.62e-01 | 0.1149 |
| 7784 | ZP3 | P16T-E | Human | Esophagus | ESCC | 2.16e-23 | 4.82e-01 | 0.1153 |
| 7784 | ZP3 | P17T-E | Human | Esophagus | ESCC | 1.16e-07 | 2.72e-01 | 0.1278 |
| 7784 | ZP3 | P20T-E | Human | Esophagus | ESCC | 1.92e-12 | 3.01e-01 | 0.1124 |
| 7784 | ZP3 | P21T-E | Human | Esophagus | ESCC | 2.30e-21 | 4.87e-01 | 0.1617 |
| 7784 | ZP3 | P22T-E | Human | Esophagus | ESCC | 4.20e-03 | 8.55e-02 | 0.1236 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
| GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
| GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
| GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
| GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
| GO:0045927 | Colorectum | AD | positive regulation of growth | 77/3918 | 259/18723 | 4.82e-04 | 5.27e-03 | 77 |
| GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
| GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
| GO:0048638 | Colorectum | AD | regulation of developmental growth | 92/3918 | 330/18723 | 1.48e-03 | 1.25e-02 | 92 |
| GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
| GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
| GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
| GO:0048639 | Colorectum | AD | positive regulation of developmental growth | 52/3918 | 174/18723 | 3.24e-03 | 2.38e-02 | 52 |
| GO:00485112 | Colorectum | MSS | rhythmic process | 89/3467 | 298/18723 | 1.17e-06 | 3.96e-05 | 89 |
| GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
| GO:00486082 | Colorectum | MSS | reproductive structure development | 113/3467 | 424/18723 | 1.94e-05 | 4.18e-04 | 113 |
| GO:00017012 | Colorectum | MSS | in utero embryonic development | 99/3467 | 367/18723 | 3.71e-05 | 7.10e-04 | 99 |
| GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
| GO:19035321 | Colorectum | MSS | positive regulation of secretion by cell | 74/3467 | 282/18723 | 7.93e-04 | 8.36e-03 | 74 |
| GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZP3 | SNV | Missense_Mutation | c.52N>A | p.Glu18Lys | p.E18K | P21754 | protein_coding | tolerated(0.14) | possibly_damaging(0.815) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ZP3 | SNV | Missense_Mutation | rs760550498 | c.1199N>C | p.Leu400Pro | p.L400P | P21754 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| ZP3 | SNV | Missense_Mutation | rs370377360 | c.115N>A | p.Val39Ile | p.V39I | P21754 | protein_coding | tolerated(0.15) | benign(0.014) | TCGA-AO-A12H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
| ZP3 | SNV | Missense_Mutation | c.550N>A | p.Glu184Lys | p.E184K | P21754 | protein_coding | tolerated(0.11) | benign(0.022) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| ZP3 | SNV | Missense_Mutation | novel | c.1144N>T | p.Pro382Ser | p.P382S | P21754 | protein_coding | tolerated(0.43) | benign(0) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| ZP3 | SNV | Missense_Mutation | c.130N>T | p.Val44Leu | p.V44L | P21754 | protein_coding | deleterious(0.02) | benign(0.01) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZP3 | SNV | Missense_Mutation | rs144871193 | c.322N>A | p.Asp108Asn | p.D108N | P21754 | protein_coding | tolerated(0.05) | benign(0.046) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ZP3 | SNV | Missense_Mutation | c.125N>C | p.Val42Ala | p.V42A | P21754 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZP3 | SNV | Missense_Mutation | c.474G>T | p.Leu158Phe | p.L158F | P21754 | protein_coding | deleterious(0.01) | benign(0.215) | TCGA-AG-4007-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
| ZP3 | SNV | Missense_Mutation | novel | c.361C>T | p.Arg121Cys | p.R121C | P21754 | protein_coding | deleterious(0.04) | possibly_damaging(0.899) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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