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Gene: ZNRF2 |
Gene summary for ZNRF2 |
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Gene information | Species | Human | Gene symbol | ZNRF2 | Gene ID | 223082 |
Gene name | zinc and ring finger 2 | |
Gene Alias | RNF202 | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A090N8Y8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
223082 | ZNRF2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.63e-11 | -4.73e-01 | 0.0155 |
223082 | ZNRF2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.93e-03 | -2.70e-01 | -0.1464 |
223082 | ZNRF2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.95e-04 | -5.12e-01 | 0.0338 |
223082 | ZNRF2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.21e-03 | -2.50e-01 | 0.0674 |
223082 | ZNRF2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.68e-03 | -3.95e-01 | 0.0588 |
223082 | ZNRF2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.91e-06 | -3.04e-01 | 0.294 |
223082 | ZNRF2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.05e-12 | -3.95e-01 | 0.3005 |
223082 | ZNRF2 | A001-C-207 | Human | Colorectum | FAP | 3.63e-05 | -3.96e-01 | 0.1278 |
223082 | ZNRF2 | A015-C-203 | Human | Colorectum | FAP | 4.80e-34 | -5.43e-01 | -0.1294 |
223082 | ZNRF2 | A015-C-204 | Human | Colorectum | FAP | 4.05e-06 | -3.89e-01 | -0.0228 |
223082 | ZNRF2 | A014-C-040 | Human | Colorectum | FAP | 9.05e-03 | -4.30e-01 | -0.1184 |
223082 | ZNRF2 | A002-C-201 | Human | Colorectum | FAP | 9.26e-14 | -4.34e-01 | 0.0324 |
223082 | ZNRF2 | A002-C-203 | Human | Colorectum | FAP | 4.66e-05 | -4.18e-02 | 0.2786 |
223082 | ZNRF2 | A001-C-119 | Human | Colorectum | FAP | 3.42e-14 | -6.08e-01 | -0.1557 |
223082 | ZNRF2 | A001-C-108 | Human | Colorectum | FAP | 2.29e-23 | -4.66e-01 | -0.0272 |
223082 | ZNRF2 | A002-C-205 | Human | Colorectum | FAP | 6.37e-23 | -5.90e-01 | -0.1236 |
223082 | ZNRF2 | A001-C-104 | Human | Colorectum | FAP | 3.71e-13 | -4.70e-01 | 0.0184 |
223082 | ZNRF2 | A015-C-005 | Human | Colorectum | FAP | 6.89e-06 | -3.57e-01 | -0.0336 |
223082 | ZNRF2 | A015-C-006 | Human | Colorectum | FAP | 4.67e-15 | -5.75e-01 | -0.0994 |
223082 | ZNRF2 | A015-C-106 | Human | Colorectum | FAP | 6.06e-19 | -3.96e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNRF2 | SNV | Missense_Mutation | c.511G>A | p.Glu171Lys | p.E171K | Q8NHG8 | protein_coding | deleterious(0) | benign(0.118) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ZNRF2 | SNV | Missense_Mutation | c.712N>C | p.Glu238Gln | p.E238Q | Q8NHG8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
ZNRF2 | SNV | Missense_Mutation | c.704N>A | p.Ser235Tyr | p.S235Y | Q8NHG8 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNRF2 | SNV | Missense_Mutation | novel | c.581N>C | p.Lys194Thr | p.K194T | Q8NHG8 | protein_coding | deleterious(0) | benign(0.053) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNRF2 | SNV | Missense_Mutation | c.494N>C | p.Lys165Thr | p.K165T | Q8NHG8 | protein_coding | deleterious(0) | possibly_damaging(0.574) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNRF2 | SNV | Missense_Mutation | c.551G>T | p.Arg184Leu | p.R184L | Q8NHG8 | protein_coding | deleterious(0.03) | possibly_damaging(0.663) | TCGA-37-4135-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNRF2 | SNV | Missense_Mutation | novel | c.455C>A | p.Pro152Gln | p.P152Q | Q8NHG8 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-CN-6995-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNRF2 | SNV | Missense_Mutation | c.715N>A | p.His239Asn | p.H239N | Q8NHG8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EJ-5496-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
ZNRF2 | SNV | Missense_Mutation | novel | c.683N>G | p.Glu228Gly | p.E228G | Q8NHG8 | protein_coding | deleterious(0) | possibly_damaging(0.636) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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