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Gene: ZNRD2 |
Gene summary for ZNRD2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNRD2 | Gene ID | 10534 |
| Gene name | zinc ribbon domain containing 2 | |
| Gene Alias | SSSCA1 | |
| Cytomap | 11q13.1 | |
| Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | G3V1B8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10534 | ZNRD2 | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 6.08e-01 | 0.082 |
| 10534 | ZNRD2 | LZE3D | Human | Esophagus | HGIN | 3.66e-03 | 4.85e-01 | 0.0668 |
| 10534 | ZNRD2 | LZE4T | Human | Esophagus | ESCC | 3.06e-21 | 5.54e-01 | 0.0811 |
| 10534 | ZNRD2 | LZE5T | Human | Esophagus | ESCC | 1.40e-06 | 5.15e-01 | 0.0514 |
| 10534 | ZNRD2 | LZE7T | Human | Esophagus | ESCC | 8.99e-32 | 9.68e-01 | 0.0667 |
| 10534 | ZNRD2 | LZE8T | Human | Esophagus | ESCC | 1.16e-16 | 5.33e-01 | 0.067 |
| 10534 | ZNRD2 | LZE20T | Human | Esophagus | ESCC | 3.73e-46 | 1.16e+00 | 0.0662 |
| 10534 | ZNRD2 | LZE22D1 | Human | Esophagus | HGIN | 4.30e-07 | 2.74e-01 | 0.0595 |
| 10534 | ZNRD2 | LZE22T | Human | Esophagus | ESCC | 1.15e-08 | 4.90e-01 | 0.068 |
| 10534 | ZNRD2 | LZE24T | Human | Esophagus | ESCC | 6.03e-37 | 8.37e-01 | 0.0596 |
| 10534 | ZNRD2 | LZE22D3 | Human | Esophagus | HGIN | 4.92e-04 | 7.78e-01 | 0.0653 |
| 10534 | ZNRD2 | LZE21T | Human | Esophagus | ESCC | 1.57e-07 | 5.66e-01 | 0.0655 |
| 10534 | ZNRD2 | LZE6T | Human | Esophagus | ESCC | 1.07e-15 | 5.91e-01 | 0.0845 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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