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Gene: ZNHIT1 |
Gene summary for ZNHIT1 |
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Gene information | Species | Human | Gene symbol | ZNHIT1 | Gene ID | 10467 |
Gene name | zinc finger HIT-type containing 1 | |
Gene Alias | CG1I | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006325 | UniProtAcc | O43257 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10467 | ZNHIT1 | GSM4909280 | Human | Breast | Precancer | 2.56e-02 | -4.03e-01 | 0.0305 |
10467 | ZNHIT1 | GSM4909281 | Human | Breast | IDC | 1.25e-02 | 2.85e-01 | 0.21 |
10467 | ZNHIT1 | GSM4909285 | Human | Breast | IDC | 1.45e-04 | -2.24e-01 | 0.21 |
10467 | ZNHIT1 | GSM4909286 | Human | Breast | IDC | 2.53e-11 | 4.04e-01 | 0.1081 |
10467 | ZNHIT1 | GSM4909288 | Human | Breast | IDC | 3.40e-02 | -5.47e-02 | 0.0988 |
10467 | ZNHIT1 | GSM4909293 | Human | Breast | IDC | 6.77e-15 | 4.51e-01 | 0.1581 |
10467 | ZNHIT1 | GSM4909294 | Human | Breast | IDC | 3.04e-06 | 2.32e-01 | 0.2022 |
10467 | ZNHIT1 | GSM4909296 | Human | Breast | IDC | 1.45e-19 | 4.10e-01 | 0.1524 |
10467 | ZNHIT1 | GSM4909297 | Human | Breast | IDC | 1.46e-13 | -1.57e-01 | 0.1517 |
10467 | ZNHIT1 | GSM4909301 | Human | Breast | IDC | 3.21e-09 | 3.85e-01 | 0.1577 |
10467 | ZNHIT1 | GSM4909302 | Human | Breast | IDC | 7.37e-10 | 4.01e-01 | 0.1545 |
10467 | ZNHIT1 | GSM4909304 | Human | Breast | IDC | 5.44e-33 | 6.90e-01 | 0.1636 |
10467 | ZNHIT1 | GSM4909306 | Human | Breast | IDC | 8.48e-05 | 3.65e-01 | 0.1564 |
10467 | ZNHIT1 | GSM4909308 | Human | Breast | IDC | 1.11e-02 | 2.84e-01 | 0.158 |
10467 | ZNHIT1 | GSM4909311 | Human | Breast | IDC | 1.34e-34 | -2.37e-01 | 0.1534 |
10467 | ZNHIT1 | GSM4909312 | Human | Breast | IDC | 3.21e-11 | -3.15e-02 | 0.1552 |
10467 | ZNHIT1 | GSM4909313 | Human | Breast | IDC | 2.56e-02 | 7.28e-02 | 0.0391 |
10467 | ZNHIT1 | GSM4909315 | Human | Breast | IDC | 2.79e-36 | 7.50e-01 | 0.21 |
10467 | ZNHIT1 | GSM4909316 | Human | Breast | IDC | 4.12e-20 | 6.27e-01 | 0.21 |
10467 | ZNHIT1 | GSM4909317 | Human | Breast | IDC | 2.13e-04 | 3.71e-01 | 0.1355 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00063381 | Cervix | CC | chromatin remodeling | 45/2311 | 255/18723 | 8.33e-03 | 4.30e-02 | 45 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:000632513 | Endometrium | EEC | chromatin organization | 65/2168 | 409/18723 | 4.98e-03 | 3.14e-02 | 65 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:0043486 | Esophagus | ESCC | histone exchange | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:00063259 | Prostate | BPH | chromatin organization | 101/3107 | 409/18723 | 1.52e-05 | 1.94e-04 | 101 |
GO:00063382 | Prostate | BPH | chromatin remodeling | 62/3107 | 255/18723 | 9.47e-04 | 5.97e-03 | 62 |
GO:000632514 | Prostate | Tumor | chromatin organization | 104/3246 | 409/18723 | 2.02e-05 | 2.62e-04 | 104 |
GO:000633811 | Prostate | Tumor | chromatin remodeling | 63/3246 | 255/18723 | 1.73e-03 | 1.02e-02 | 63 |
GO:000632519 | Skin | cSCC | chromatin organization | 147/4864 | 409/18723 | 4.41e-06 | 6.52e-05 | 147 |
GO:000633812 | Skin | cSCC | chromatin remodeling | 94/4864 | 255/18723 | 7.58e-05 | 7.26e-04 | 94 |
GO:00718241 | Skin | cSCC | protein-DNA complex subunit organization | 87/4864 | 241/18723 | 3.09e-04 | 2.47e-03 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNHIT1 | SNV | Missense_Mutation | c.320N>A | p.Gly107Glu | p.G107E | O43257 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNHIT1 | SNV | Missense_Mutation | c.341N>A | p.Arg114His | p.R114H | O43257 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNHIT1 | SNV | Missense_Mutation | rs764694500 | c.77G>A | p.Arg26His | p.R26H | O43257 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNHIT1 | SNV | Missense_Mutation | rs749784309 | c.137N>T | p.Ala46Val | p.A46V | O43257 | protein_coding | deleterious(0.04) | possibly_damaging(0.569) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZNHIT1 | SNV | Missense_Mutation | rs200966635 | c.80G>A | p.Arg27His | p.R27H | O43257 | protein_coding | tolerated(0.05) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNHIT1 | SNV | Missense_Mutation | novel | c.434N>C | p.Gln145Pro | p.Q145P | O43257 | protein_coding | tolerated(0.09) | benign(0.092) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNHIT1 | SNV | Missense_Mutation | c.235N>T | p.Arg79Cys | p.R79C | O43257 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ZNHIT1 | SNV | Missense_Mutation | c.398N>T | p.Ala133Val | p.A133V | O43257 | protein_coding | tolerated(0.06) | possibly_damaging(0.46) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNHIT1 | SNV | Missense_Mutation | novel | c.250N>G | p.Phe84Val | p.F84V | O43257 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNHIT1 | SNV | Missense_Mutation | novel | c.49N>T | p.Arg17Trp | p.R17W | O43257 | protein_coding | deleterious(0.04) | possibly_damaging(0.876) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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