![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF841 |
Gene summary for ZNF841 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF841 | Gene ID | 284371 |
Gene name | zinc finger protein 841 | |
Gene Alias | ZNF841 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZN19 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284371 | ZNF841 | LZE7T | Human | Esophagus | ESCC | 3.90e-02 | 1.71e-01 | 0.0667 |
284371 | ZNF841 | LZE8T | Human | Esophagus | ESCC | 4.41e-02 | 1.27e-01 | 0.067 |
284371 | ZNF841 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.36e-01 | 0.0662 |
284371 | ZNF841 | P1T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.53e-01 | 0.0875 |
284371 | ZNF841 | P2T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.99e-01 | 0.1177 |
284371 | ZNF841 | P4T-E | Human | Esophagus | ESCC | 2.45e-12 | 2.73e-01 | 0.1323 |
284371 | ZNF841 | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.24e-01 | 0.1327 |
284371 | ZNF841 | P8T-E | Human | Esophagus | ESCC | 1.41e-40 | 6.89e-01 | 0.0889 |
284371 | ZNF841 | P10T-E | Human | Esophagus | ESCC | 1.47e-14 | 3.23e-01 | 0.116 |
284371 | ZNF841 | P11T-E | Human | Esophagus | ESCC | 1.20e-09 | 3.43e-01 | 0.1426 |
284371 | ZNF841 | P12T-E | Human | Esophagus | ESCC | 5.27e-10 | 2.41e-01 | 0.1122 |
284371 | ZNF841 | P15T-E | Human | Esophagus | ESCC | 3.34e-06 | 1.52e-01 | 0.1149 |
284371 | ZNF841 | P16T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.26e-01 | 0.1153 |
284371 | ZNF841 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 2.76e-01 | 0.1662 |
284371 | ZNF841 | P21T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.79e-01 | 0.1617 |
284371 | ZNF841 | P22T-E | Human | Esophagus | ESCC | 1.77e-22 | 3.55e-01 | 0.1236 |
284371 | ZNF841 | P23T-E | Human | Esophagus | ESCC | 1.48e-05 | 1.43e-01 | 0.108 |
284371 | ZNF841 | P26T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.17e-01 | 0.1276 |
284371 | ZNF841 | P27T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.88e-01 | 0.1055 |
284371 | ZNF841 | P28T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.14e-01 | 0.1149 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF841 | SNV | Missense_Mutation | novel | c.49N>C | p.Phe17Leu | p.F17L | Q6ZN19 | protein_coding | deleterious(0.01) | benign(0.156) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF841 | SNV | Missense_Mutation | rs749554827 | c.2413N>T | p.Arg805Cys | p.R805C | Q6ZN19 | protein_coding | tolerated(0.2) | possibly_damaging(0.745) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF841 | SNV | Missense_Mutation | novel | c.1950N>T | p.Glu650Asp | p.E650D | Q6ZN19 | protein_coding | deleterious(0.03) | possibly_damaging(0.829) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF841 | SNV | Missense_Mutation | novel | c.567G>C | p.Gln189His | p.Q189H | Q6ZN19 | protein_coding | tolerated(0.48) | possibly_damaging(0.773) | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF841 | SNV | Missense_Mutation | novel | c.567N>C | p.Gln189His | p.Q189H | Q6ZN19 | protein_coding | tolerated(0.48) | possibly_damaging(0.773) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF841 | SNV | Missense_Mutation | c.2033N>C | p.Glu678Ala | p.E678A | Q6ZN19 | protein_coding | deleterious(0) | benign(0.202) | TCGA-AO-A03L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
ZNF841 | SNV | Missense_Mutation | c.2323N>T | p.Arg775Cys | p.R775C | Q6ZN19 | protein_coding | tolerated(0.15) | possibly_damaging(0.83) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF841 | SNV | Missense_Mutation | c.1048N>G | p.Cys350Gly | p.C350G | Q6ZN19 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
ZNF841 | SNV | Missense_Mutation | c.1463N>G | p.Asn488Ser | p.N488S | Q6ZN19 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF841 | SNV | Missense_Mutation | c.1804N>G | p.Cys602Gly | p.C602G | Q6ZN19 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-BH-A0C1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |