|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: ZNF812P |
Gene summary for ZNF812P |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF812P | Gene ID | 729648 |
| Gene name | zinc finger protein 812, pseudogene | |
| Gene Alias | ZNF812 | |
| Cytomap | 19p13.2 | |
| Gene Type | pseudo | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 729648 | ZNF812P | P1T-E | Human | Esophagus | ESCC | 5.75e-15 | 7.70e-01 | 0.0875 |
| 729648 | ZNF812P | P9T-E | Human | Esophagus | ESCC | 6.74e-06 | 1.69e-01 | 0.1131 |
| 729648 | ZNF812P | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 1.56e-01 | 0.1426 |
| 729648 | ZNF812P | P20T-E | Human | Esophagus | ESCC | 9.00e-22 | 5.83e-01 | 0.1124 |
| 729648 | ZNF812P | P21T-E | Human | Esophagus | ESCC | 7.31e-14 | 3.04e-01 | 0.1617 |
| 729648 | ZNF812P | P23T-E | Human | Esophagus | ESCC | 4.96e-26 | 7.27e-01 | 0.108 |
| 729648 | ZNF812P | P27T-E | Human | Esophagus | ESCC | 2.86e-20 | 4.20e-01 | 0.1055 |
| 729648 | ZNF812P | P28T-E | Human | Esophagus | ESCC | 1.00e-24 | 5.73e-01 | 0.1149 |
| 729648 | ZNF812P | P32T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.82e-01 | 0.1666 |
| 729648 | ZNF812P | P39T-E | Human | Esophagus | ESCC | 2.87e-41 | 8.95e-01 | 0.0894 |
| 729648 | ZNF812P | P40T-E | Human | Esophagus | ESCC | 1.20e-04 | 2.74e-01 | 0.109 |
| 729648 | ZNF812P | P47T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.70e-01 | 0.1067 |
| 729648 | ZNF812P | P48T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.98e-01 | 0.0959 |
| 729648 | ZNF812P | P54T-E | Human | Esophagus | ESCC | 1.11e-22 | 5.96e-01 | 0.0975 |
| 729648 | ZNF812P | P62T-E | Human | Esophagus | ESCC | 7.09e-58 | 9.43e-01 | 0.1302 |
| 729648 | ZNF812P | P65T-E | Human | Esophagus | ESCC | 7.69e-05 | 1.93e-01 | 0.0978 |
| 729648 | ZNF812P | P79T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.63e-02 | 0.1154 |
| 729648 | ZNF812P | P80T-E | Human | Esophagus | ESCC | 2.37e-09 | 2.75e-01 | 0.155 |
| 729648 | ZNF812P | P82T-E | Human | Esophagus | ESCC | 6.28e-04 | 2.19e-01 | 0.1072 |
| 729648 | ZNF812P | P84T-E | Human | Esophagus | ESCC | 1.34e-04 | 3.47e-01 | 0.0933 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |