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Gene: ZNF787 |
Gene summary for ZNF787 |
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Gene information | Species | Human | Gene symbol | ZNF787 | Gene ID | 126208 |
Gene name | zinc finger protein 787 | |
Gene Alias | TIP20 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6DD87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126208 | ZNF787 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.25e-05 | 6.82e-02 | 0.0155 |
126208 | ZNF787 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.32e-02 | 3.79e-01 | -0.0811 |
126208 | ZNF787 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.64e-12 | 4.67e-01 | -0.1954 |
126208 | ZNF787 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.18e-03 | 3.44e-01 | -0.1207 |
126208 | ZNF787 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.14e-02 | 2.77e-01 | -0.1526 |
126208 | ZNF787 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.98e-15 | 4.70e-01 | -0.1464 |
126208 | ZNF787 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.56e-08 | 3.51e-01 | -0.1001 |
126208 | ZNF787 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.78e-10 | 5.22e-01 | -0.059 |
126208 | ZNF787 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.96e-02 | 3.32e-01 | -0.0842 |
126208 | ZNF787 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.05e-02 | 4.25e-01 | -0.0177 |
126208 | ZNF787 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.20e-07 | 5.35e-01 | 0.0338 |
126208 | ZNF787 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.36e-26 | 8.42e-01 | 0.0674 |
126208 | ZNF787 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.30e-07 | 3.99e-01 | 0.3859 |
126208 | ZNF787 | HCC1_Meng | Human | Liver | HCC | 3.10e-47 | 1.42e-01 | 0.0246 |
126208 | ZNF787 | HCC2_Meng | Human | Liver | HCC | 1.96e-17 | 1.64e-01 | 0.0107 |
126208 | ZNF787 | HCC2 | Human | Liver | HCC | 1.97e-15 | 2.81e+00 | 0.5341 |
126208 | ZNF787 | S016 | Human | Liver | HCC | 3.04e-08 | 3.27e-01 | 0.2243 |
126208 | ZNF787 | S027 | Human | Liver | HCC | 6.60e-06 | 5.96e-01 | 0.2446 |
126208 | ZNF787 | S028 | Human | Liver | HCC | 5.74e-07 | 4.09e-01 | 0.2503 |
126208 | ZNF787 | S029 | Human | Liver | HCC | 7.73e-05 | 3.20e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF787 | insertion | Frame_Shift_Ins | novel | c.24_25insCCATGGCGTGTGGAGTCCCG | p.Ser9ProfsTer80 | p.S9Pfs*80 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |||
ZNF787 | SNV | Missense_Mutation | novel | c.341N>A | p.Arg114His | p.R114H | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF787 | SNV | Missense_Mutation | novel | c.257N>A | p.Arg86His | p.R86H | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF787 | SNV | Missense_Mutation | novel | c.424N>G | p.Arg142Gly | p.R142G | protein_coding | deleterious(0) | possibly_damaging(0.483) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF787 | SNV | Missense_Mutation | novel | c.1080G>T | p.Glu360Asp | p.E360D | protein_coding | tolerated_low_confidence(0.55) | benign(0.003) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF787 | SNV | Missense_Mutation | novel | c.1027N>A | p.Ala343Thr | p.A343T | protein_coding | deleterious(0.01) | benign(0) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF787 | SNV | Missense_Mutation | novel | c.350C>T | p.Thr117Met | p.T117M | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF787 | SNV | Missense_Mutation | novel | c.338N>A | p.Arg113Gln | p.R113Q | protein_coding | tolerated(1) | benign(0.052) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF787 | SNV | Missense_Mutation | novel | c.317N>A | p.Ser106Asn | p.S106N | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF787 | SNV | Missense_Mutation | novel | c.257N>A | p.Arg86His | p.R86H | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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