![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF773 |
Gene summary for ZNF773 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF773 | Gene ID | 374928 |
Gene name | zinc finger protein 773 | |
Gene Alias | ZNF419B | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6PK81 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374928 | ZNF773 | HCC1 | Human | Liver | HCC | 3.54e-11 | 1.87e+00 | 0.5336 |
374928 | ZNF773 | HCC2 | Human | Liver | HCC | 2.50e-09 | 8.46e-01 | 0.5341 |
374928 | ZNF773 | HCC5 | Human | Liver | HCC | 2.46e-18 | 1.18e+00 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF773 | SNV | Missense_Mutation | novel | c.425N>C | p.Leu142Pro | p.L142P | Q6PK81 | protein_coding | tolerated(0.16) | possibly_damaging(0.577) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF773 | SNV | Missense_Mutation | c.748N>G | p.Ser250Gly | p.S250G | Q6PK81 | protein_coding | tolerated(0.36) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
ZNF773 | SNV | Missense_Mutation | c.488T>C | p.Leu163Pro | p.L163P | Q6PK81 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-E9-A22B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ZNF773 | insertion | Frame_Shift_Ins | novel | c.840_841insACTT | p.Gly281ThrfsTer8 | p.G281Tfs*8 | Q6PK81 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ZNF773 | insertion | Frame_Shift_Ins | novel | c.841_842insCATCTTCCAAGACCCAT | p.Gly281AlafsTer26 | p.G281Afs*26 | Q6PK81 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ZNF773 | insertion | Nonsense_Mutation | novel | c.483_484insATTTGATTGTATTTGGGAAACACAATCTGGGG | p.Val162IlefsTer2 | p.V162Ifs*2 | Q6PK81 | protein_coding | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
ZNF773 | insertion | Frame_Shift_Ins | novel | c.515_516insCC | p.Glu172AspfsTer69 | p.E172Dfs*69 | Q6PK81 | protein_coding | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR | ||
ZNF773 | insertion | Frame_Shift_Ins | novel | c.516_517insCAATGTGATGCTGGAGAACTTTACACTTCTGGCCTCTCTGGGT | p.Lys173GlnfsTer15 | p.K173Qfs*15 | Q6PK81 | protein_coding | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR | ||
ZNF773 | SNV | Missense_Mutation | c.643G>T | p.Gly215Trp | p.G215W | Q6PK81 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF773 | SNV | Missense_Mutation | c.644G>C | p.Gly215Ala | p.G215A | Q6PK81 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |