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Gene: ZNF76 |
Gene summary for ZNF76 |
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Gene information | Species | Human | Gene symbol | ZNF76 | Gene ID | 7629 |
Gene name | zinc finger protein 76 | |
Gene Alias | D6S229E | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RCW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7629 | ZNF76 | LZE7T | Human | Esophagus | ESCC | 3.55e-07 | 3.69e-01 | 0.0667 |
7629 | ZNF76 | LZE20T | Human | Esophagus | ESCC | 1.39e-05 | 1.34e-01 | 0.0662 |
7629 | ZNF76 | LZE24T | Human | Esophagus | ESCC | 1.87e-09 | 3.18e-01 | 0.0596 |
7629 | ZNF76 | LZE21T | Human | Esophagus | ESCC | 1.98e-06 | 2.46e-01 | 0.0655 |
7629 | ZNF76 | P1T-E | Human | Esophagus | ESCC | 6.00e-07 | 3.51e-01 | 0.0875 |
7629 | ZNF76 | P2T-E | Human | Esophagus | ESCC | 1.20e-24 | 3.92e-01 | 0.1177 |
7629 | ZNF76 | P4T-E | Human | Esophagus | ESCC | 4.05e-07 | 1.92e-01 | 0.1323 |
7629 | ZNF76 | P8T-E | Human | Esophagus | ESCC | 1.23e-13 | 1.79e-01 | 0.0889 |
7629 | ZNF76 | P9T-E | Human | Esophagus | ESCC | 8.68e-04 | 9.82e-02 | 0.1131 |
7629 | ZNF76 | P10T-E | Human | Esophagus | ESCC | 4.89e-15 | 1.42e-01 | 0.116 |
7629 | ZNF76 | P11T-E | Human | Esophagus | ESCC | 3.35e-10 | 3.72e-01 | 0.1426 |
7629 | ZNF76 | P12T-E | Human | Esophagus | ESCC | 5.06e-12 | 1.62e-01 | 0.1122 |
7629 | ZNF76 | P15T-E | Human | Esophagus | ESCC | 6.99e-07 | 1.04e-01 | 0.1149 |
7629 | ZNF76 | P16T-E | Human | Esophagus | ESCC | 6.03e-13 | 3.00e-01 | 0.1153 |
7629 | ZNF76 | P17T-E | Human | Esophagus | ESCC | 3.03e-08 | 3.14e-01 | 0.1278 |
7629 | ZNF76 | P19T-E | Human | Esophagus | ESCC | 1.02e-05 | 2.84e-01 | 0.1662 |
7629 | ZNF76 | P20T-E | Human | Esophagus | ESCC | 3.81e-12 | 1.41e-01 | 0.1124 |
7629 | ZNF76 | P21T-E | Human | Esophagus | ESCC | 4.64e-12 | 1.57e-01 | 0.1617 |
7629 | ZNF76 | P22T-E | Human | Esophagus | ESCC | 1.34e-16 | 2.30e-01 | 0.1236 |
7629 | ZNF76 | P23T-E | Human | Esophagus | ESCC | 3.76e-09 | 1.98e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:0006359 | Esophagus | ESCC | regulation of transcription by RNA polymerase III | 19/8552 | 22/18723 | 9.52e-05 | 6.78e-04 | 19 |
GO:0006383 | Liver | HCC | transcription by RNA polymerase III | 31/7958 | 46/18723 | 5.67e-04 | 3.61e-03 | 31 |
GO:00063832 | Oral cavity | OSCC | transcription by RNA polymerase III | 34/7305 | 46/18723 | 1.61e-06 | 2.11e-05 | 34 |
GO:00063831 | Oral cavity | LP | transcription by RNA polymerase III | 20/4623 | 46/18723 | 4.03e-03 | 2.61e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF76 | SNV | Missense_Mutation | c.1522G>T | p.Val508Leu | p.V508L | P36508 | protein_coding | tolerated(0.2) | benign(0.091) | TCGA-AR-A24L-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | PD | |
ZNF76 | SNV | Missense_Mutation | c.1345N>C | p.Glu449Gln | p.E449Q | P36508 | protein_coding | tolerated(0.28) | possibly_damaging(0.702) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF76 | insertion | Nonsense_Mutation | novel | c.94_95insCATTAGTTCAAGTCTCAGCAACTTACTATTAGGTTGGA | p.Gln32ProfsTer11 | p.Q32Pfs*11 | P36508 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF76 | deletion | Frame_Shift_Del | novel | c.410delN | p.Leu138TrpfsTer45 | p.L138Wfs*45 | P36508 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNF76 | SNV | Missense_Mutation | rs551762842 | c.221G>A | p.Arg74His | p.R74H | P36508 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF76 | SNV | Missense_Mutation | rs762018098 | c.1474N>A | p.Asp492Asn | p.D492N | P36508 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF76 | SNV | Missense_Mutation | rs757088149 | c.1487C>T | p.Thr496Met | p.T496M | P36508 | protein_coding | tolerated(0.12) | possibly_damaging(0.764) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF76 | SNV | Missense_Mutation | rs375918169 | c.790N>T | p.Arg264Cys | p.R264C | P36508 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
ZNF76 | SNV | Missense_Mutation | rs757575175 | c.1265C>T | p.Ala422Val | p.A422V | P36508 | protein_coding | tolerated(0.13) | benign(0.018) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF76 | SNV | Missense_Mutation | c.1022N>G | p.His341Arg | p.H341R | P36508 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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