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Gene: ZNF75A |
Gene summary for ZNF75A |
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Gene information | Species | Human | Gene symbol | ZNF75A | Gene ID | 7627 |
Gene name | zinc finger protein 75a | |
Gene Alias | ZNF75A | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q68CU0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7627 | ZNF75A | LZE4T | Human | Esophagus | ESCC | 9.21e-03 | 1.61e-01 | 0.0811 |
7627 | ZNF75A | LZE7T | Human | Esophagus | ESCC | 4.98e-08 | 3.77e-01 | 0.0667 |
7627 | ZNF75A | LZE20T | Human | Esophagus | ESCC | 2.58e-08 | 3.10e-01 | 0.0662 |
7627 | ZNF75A | LZE24T | Human | Esophagus | ESCC | 2.64e-06 | 1.56e-01 | 0.0596 |
7627 | ZNF75A | P1T-E | Human | Esophagus | ESCC | 6.65e-13 | 4.57e-01 | 0.0875 |
7627 | ZNF75A | P2T-E | Human | Esophagus | ESCC | 4.28e-13 | 3.09e-01 | 0.1177 |
7627 | ZNF75A | P4T-E | Human | Esophagus | ESCC | 1.70e-09 | 2.20e-01 | 0.1323 |
7627 | ZNF75A | P5T-E | Human | Esophagus | ESCC | 3.71e-13 | 2.69e-01 | 0.1327 |
7627 | ZNF75A | P8T-E | Human | Esophagus | ESCC | 8.57e-30 | 6.03e-01 | 0.0889 |
7627 | ZNF75A | P10T-E | Human | Esophagus | ESCC | 2.39e-17 | 3.05e-01 | 0.116 |
7627 | ZNF75A | P11T-E | Human | Esophagus | ESCC | 1.73e-16 | 5.86e-01 | 0.1426 |
7627 | ZNF75A | P12T-E | Human | Esophagus | ESCC | 7.29e-30 | 6.07e-01 | 0.1122 |
7627 | ZNF75A | P15T-E | Human | Esophagus | ESCC | 3.69e-12 | 2.78e-01 | 0.1149 |
7627 | ZNF75A | P16T-E | Human | Esophagus | ESCC | 9.12e-06 | 1.40e-01 | 0.1153 |
7627 | ZNF75A | P17T-E | Human | Esophagus | ESCC | 4.73e-05 | 2.93e-01 | 0.1278 |
7627 | ZNF75A | P20T-E | Human | Esophagus | ESCC | 3.70e-05 | 1.31e-01 | 0.1124 |
7627 | ZNF75A | P21T-E | Human | Esophagus | ESCC | 1.59e-04 | 1.71e-01 | 0.1617 |
7627 | ZNF75A | P22T-E | Human | Esophagus | ESCC | 1.04e-12 | 2.69e-01 | 0.1236 |
7627 | ZNF75A | P24T-E | Human | Esophagus | ESCC | 2.29e-04 | 1.44e-01 | 0.1287 |
7627 | ZNF75A | P26T-E | Human | Esophagus | ESCC | 1.16e-14 | 2.53e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF75A | SNV | Missense_Mutation | c.860G>C | p.Ser287Thr | p.S287T | Q96N20 | protein_coding | tolerated(0.07) | benign(0.16) | TCGA-AO-A0J7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF75A | SNV | Missense_Mutation | c.357N>A | p.Met119Ile | p.M119I | Q96N20 | protein_coding | tolerated(0.33) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF75A | SNV | Missense_Mutation | c.34N>A | p.Asp12Asn | p.D12N | Q96N20 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AR-A24O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
ZNF75A | SNV | Missense_Mutation | novel | c.425A>G | p.Gln142Arg | p.Q142R | Q96N20 | protein_coding | tolerated(0.09) | benign(0.098) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF75A | SNV | Missense_Mutation | c.144N>T | p.Glu48Asp | p.E48D | Q96N20 | protein_coding | deleterious(0.05) | probably_damaging(0.987) | TCGA-D8-A140-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin+cyclophosphamid | SD | |
ZNF75A | SNV | Missense_Mutation | c.661T>C | p.Trp221Arg | p.W221R | Q96N20 | protein_coding | tolerated(0.07) | possibly_damaging(0.664) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF75A | SNV | Missense_Mutation | c.357N>A | p.Met119Ile | p.M119I | Q96N20 | protein_coding | tolerated(0.33) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF75A | SNV | Missense_Mutation | novel | c.168A>C | p.Gln56His | p.Q56H | Q96N20 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF75A | SNV | Missense_Mutation | novel | c.169G>T | p.Val57Leu | p.V57L | Q96N20 | protein_coding | tolerated(0.38) | benign(0.005) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF75A | SNV | Missense_Mutation | novel | c.539N>C | p.Gln180Pro | p.Q180P | Q96N20 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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