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Gene: ZNF747 |
Gene summary for ZNF747 |
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Gene information | Species | Human | Gene symbol | ZNF747 | Gene ID | 65988 |
Gene name | zinc finger protein 747 | |
Gene Alias | ZNF747 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BV97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65988 | ZNF747 | HCC1_Meng | Human | Liver | HCC | 2.02e-08 | -5.30e-03 | 0.0246 |
65988 | ZNF747 | HCC1 | Human | Liver | HCC | 1.66e-03 | 2.61e+00 | 0.5336 |
65988 | ZNF747 | HCC2 | Human | Liver | HCC | 2.26e-03 | 1.92e+00 | 0.5341 |
65988 | ZNF747 | S015 | Human | Liver | HCC | 1.12e-03 | 1.61e-01 | 0.2375 |
65988 | ZNF747 | S027 | Human | Liver | HCC | 2.97e-02 | 2.51e-01 | 0.2446 |
65988 | ZNF747 | S029 | Human | Liver | HCC | 1.98e-02 | 1.57e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF747 | SNV | Missense_Mutation | novel | c.592N>A | p.Glu198Lys | p.E198K | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZNF747 | SNV | Missense_Mutation | c.177N>C | p.Arg59Ser | p.R59S | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
ZNF747 | SNV | Missense_Mutation | rs753100886 | c.538N>T | p.Arg180Cys | p.R180C | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF747 | SNV | Missense_Mutation | novel | c.893N>A | p.Arg298His | p.R298H | protein_coding | tolerated(0.14) | benign(0.049) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
ZNF747 | SNV | Missense_Mutation | novel | c.403N>A | p.Asp135Asn | p.D135N | protein_coding | tolerated(0.52) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZNF747 | SNV | Missense_Mutation | novel | c.403N>A | p.Asp135Asn | p.D135N | protein_coding | tolerated(0.52) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
ZNF747 | SNV | Missense_Mutation | novel | c.797N>A | p.Arg266His | p.R266H | protein_coding | tolerated(0.15) | possibly_damaging(0.589) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF747 | SNV | Missense_Mutation | novel | c.445N>A | p.Ala149Thr | p.A149T | protein_coding | tolerated(0.6) | benign(0.007) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF747 | SNV | Missense_Mutation | rs758383771 | c.944N>T | p.Pro315Leu | p.P315L | protein_coding | tolerated(0.23) | possibly_damaging(0.722) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF747 | SNV | Missense_Mutation | novel | c.631N>C | p.Cys211Arg | p.C211R | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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