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Gene: ZNF713 |
Gene summary for ZNF713 |
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Gene information | Species | Human | Gene symbol | ZNF713 | Gene ID | 349075 |
Gene name | zinc finger protein 713 | |
Gene Alias | ZNF713 | |
Cytomap | 7p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0M3HEQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
349075 | ZNF713 | HCC1 | Human | Liver | HCC | 2.23e-14 | 2.63e+00 | 0.5336 |
349075 | ZNF713 | HCC2 | Human | Liver | HCC | 4.76e-25 | 2.29e+00 | 0.5341 |
349075 | ZNF713 | HCC5 | Human | Liver | HCC | 1.98e-24 | 1.49e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF713 | SNV | Missense_Mutation | c.485N>C | p.Arg162Thr | p.R162T | protein_coding | tolerated(0.26) | benign(0.162) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ZNF713 | SNV | Missense_Mutation | rs775909225 | c.8C>A | p.Ser3Tyr | p.S3Y | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF713 | insertion | In_Frame_Ins | novel | c.400_401insATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCATGAGGT | p.Ala134delinsAspProSerThrLeuGlyGlyArgGlyArgArgIleMetArgSer | p.A134delinsDPSTLGGRGRRIMRS | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF713 | insertion | In_Frame_Ins | novel | c.562_563insACTTGGGGAATGGTGTGGGTGAAATGAGTTACATTTCAC | p.Asn188_Cys189insLeuGlyAsnGlyValGlyGluMetSerTyrIleSerHis | p.N188_C189insLGNGVGEMSYISH | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | |||
ZNF713 | SNV | Missense_Mutation | novel | c.1169G>T | p.Arg390Ile | p.R390I | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF713 | SNV | Missense_Mutation | c.598A>T | p.Ile200Phe | p.I200F | protein_coding | tolerated(0.12) | possibly_damaging(0.851) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | ||
ZNF713 | SNV | Missense_Mutation | novel | c.815C>A | p.Ser272Tyr | p.S272Y | protein_coding | tolerated(1) | benign(0.087) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ZNF713 | SNV | Missense_Mutation | c.465N>A | p.Phe155Leu | p.F155L | protein_coding | tolerated(0.69) | benign(0) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ZNF713 | SNV | Missense_Mutation | rs562676563 | c.400G>A | p.Ala134Thr | p.A134T | protein_coding | tolerated(1) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF713 | SNV | Missense_Mutation | c.1265N>T | p.Arg422Leu | p.R422L | protein_coding | deleterious(0.05) | benign(0.309) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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