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Gene: ZNF708 |
Gene summary for ZNF708 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF708 | Gene ID | 7562 |
| Gene name | zinc finger protein 708 | |
| Gene Alias | KOX8 | |
| Cytomap | 19p12 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17019 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7562 | ZNF708 | male-WTA | Human | Thyroid | PTC | 1.88e-07 | 9.80e-02 | 0.1037 |
| 7562 | ZNF708 | PTC01 | Human | Thyroid | PTC | 3.99e-07 | 1.00e-01 | 0.1899 |
| 7562 | ZNF708 | PTC03 | Human | Thyroid | PTC | 1.12e-04 | 1.90e-01 | 0.1784 |
| 7562 | ZNF708 | PTC04 | Human | Thyroid | PTC | 1.60e-06 | 1.90e-01 | 0.1927 |
| 7562 | ZNF708 | PTC05 | Human | Thyroid | PTC | 7.45e-13 | 4.72e-01 | 0.2065 |
| 7562 | ZNF708 | PTC06 | Human | Thyroid | PTC | 3.33e-21 | 4.97e-01 | 0.2057 |
| 7562 | ZNF708 | PTC07 | Human | Thyroid | PTC | 2.52e-15 | 2.43e-01 | 0.2044 |
| 7562 | ZNF708 | ATC12 | Human | Thyroid | ATC | 9.15e-06 | 6.65e-02 | 0.34 |
| 7562 | ZNF708 | ATC13 | Human | Thyroid | ATC | 9.13e-46 | 8.83e-01 | 0.34 |
| 7562 | ZNF708 | ATC2 | Human | Thyroid | ATC | 8.21e-06 | 5.44e-01 | 0.34 |
| 7562 | ZNF708 | ATC4 | Human | Thyroid | ATC | 3.91e-04 | 8.99e-02 | 0.34 |
| 7562 | ZNF708 | ATC5 | Human | Thyroid | ATC | 2.70e-51 | 9.39e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF708 | CD4TN | Endometrium | ADJ | ZNF790,CASC3,FXR2, etc. | 1.11e-02 |  |
| ZNF708 | CD4TN | Endometrium | AEH | ZNF790,CASC3,FXR2, etc. | 1.30e-02 |  |
| ZNF708 | TH1 | Endometrium | AEH | ZNF790,CASC3,FXR2, etc. | 3.62e-02 | |
| ZNF708 | CD4TN | Endometrium | EEC | ZNF790,CASC3,FXR2, etc. | 7.86e-02 |  |
| ZNF708 | NK | Endometrium | Healthy | ZNF790,CASC3,FXR2, etc. | 2.68e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF708 | SNV | Missense_Mutation | novel | c.303N>C | p.Arg101Ser | p.R101S | P17019 | protein_coding | deleterious(0.04) | benign(0.141) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF708 | insertion | Frame_Shift_Ins | novel | c.497_498insA | p.Asn166LysfsTer6 | p.N166Kfs*6 | P17019 | protein_coding | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
| ZNF708 | SNV | Missense_Mutation | novel | c.425N>A | p.Cys142Tyr | p.C142Y | P17019 | protein_coding | deleterious(0.04) | benign(0.168) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ZNF708 | SNV | Missense_Mutation | c.427N>C | p.Asp143His | p.D143H | P17019 | protein_coding | tolerated(0.14) | benign(0.029) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZNF708 | SNV | Missense_Mutation | novel | c.1606N>A | p.Glu536Lys | p.E536K | P17019 | protein_coding | tolerated(0.08) | benign(0.112) | TCGA-VS-A957-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ZNF708 | SNV | Missense_Mutation | novel | c.1086A>C | p.Lys362Asn | p.K362N | P17019 | protein_coding | deleterious(0.01) | probably_damaging(0.958) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| ZNF708 | SNV | Missense_Mutation | rs760773229 | c.1655G>T | p.Arg552Ile | p.R552I | P17019 | protein_coding | tolerated(0.45) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF708 | SNV | Missense_Mutation | c.736C>A | p.His246Asn | p.H246N | P17019 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| ZNF708 | SNV | Missense_Mutation | c.1637A>G | p.Asn546Ser | p.N546S | P17019 | protein_coding | tolerated(0.87) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| ZNF708 | SNV | Missense_Mutation | c.1499G>A | p.Gly500Glu | p.G500E | P17019 | protein_coding | tolerated(0.08) | possibly_damaging(0.79) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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