![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF704 |
Gene summary for ZNF704 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF704 | Gene ID | 619279 |
Gene name | zinc finger protein 704 | |
Gene Alias | Gig1 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZNC4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
619279 | ZNF704 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.98e-29 | -7.78e-01 | 0.0155 |
619279 | ZNF704 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.78e-15 | -7.42e-01 | -0.1808 |
619279 | ZNF704 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.34e-04 | -8.07e-01 | 0.0216 |
619279 | ZNF704 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.60e-03 | -4.64e-01 | -0.0811 |
619279 | ZNF704 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.22e-02 | -6.04e-01 | -0.2196 |
619279 | ZNF704 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.04e-11 | -7.22e-01 | -0.1207 |
619279 | ZNF704 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.19e-03 | -2.79e-01 | -0.1464 |
619279 | ZNF704 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.04e-04 | -2.69e-01 | -0.1001 |
619279 | ZNF704 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.05e-07 | -4.81e-01 | -0.059 |
619279 | ZNF704 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.03e-05 | -7.20e-01 | -0.2061 |
619279 | ZNF704 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.65e-03 | -7.20e-01 | -0.1462 |
619279 | ZNF704 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.15e-13 | -5.56e-01 | 0.096 |
619279 | ZNF704 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.33e-06 | -7.53e-01 | 0.0528 |
619279 | ZNF704 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.35e-03 | -4.19e-01 | 0.0338 |
619279 | ZNF704 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.63e-10 | -3.88e-01 | 0.0674 |
619279 | ZNF704 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.04e-21 | -5.58e-01 | 0.294 |
619279 | ZNF704 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.89e-12 | -8.30e-01 | 0.2585 |
619279 | ZNF704 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.65e-33 | -7.83e-01 | 0.3005 |
619279 | ZNF704 | F007 | Human | Colorectum | FAP | 4.19e-03 | -1.91e-01 | 0.1176 |
619279 | ZNF704 | A015-C-203 | Human | Colorectum | FAP | 6.41e-23 | -3.66e-01 | -0.1294 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF704 | SNV | Missense_Mutation | rs752885224 | c.1157G>A | p.Arg386Gln | p.R386Q | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ZNF704 | SNV | Missense_Mutation | novel | c.119N>T | p.Ala40Val | p.A40V | Q6ZNC4 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF704 | insertion | Nonsense_Mutation | novel | c.733_734insAAATAAAATGTAAGCATTGGAAAGCTTTGGCA | p.Ser245Ter | p.S245* | Q6ZNC4 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
ZNF704 | SNV | Missense_Mutation | c.1063N>A | p.Gly355Arg | p.G355R | Q6ZNC4 | protein_coding | tolerated(0.28) | probably_damaging(0.911) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF704 | SNV | Missense_Mutation | c.824N>A | p.Arg275Gln | p.R275Q | Q6ZNC4 | protein_coding | tolerated(0.34) | benign(0.014) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF704 | SNV | Missense_Mutation | c.1040N>T | p.Pro347Leu | p.P347L | Q6ZNC4 | protein_coding | tolerated(0.14) | probably_damaging(0.998) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF704 | SNV | Missense_Mutation | novel | c.46N>C | p.Lys16Gln | p.K16Q | Q6ZNC4 | protein_coding | tolerated_low_confidence(0.52) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF704 | SNV | Missense_Mutation | rs139476385 | c.1052C>T | p.Pro351Leu | p.P351L | Q6ZNC4 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-CM-6161-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | rs752885224 | c.1157G>A | p.Arg386Gln | p.R386Q | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF704 | SNV | Missense_Mutation | c.980N>A | p.Ser327Asn | p.S327N | Q6ZNC4 | protein_coding | tolerated(0.58) | benign(0.003) | TCGA-G4-6294-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |