Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZNF7

Gene summary for ZNF7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZNF7

Gene ID

7553

Gene namezinc finger protein 7
Gene AliasHF.16
Cytomap8q24.3
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

P17097


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7553ZNF7LZE4THumanEsophagusESCC1.48e-102.21e-010.0811
7553ZNF7LZE8THumanEsophagusESCC2.48e-041.47e-010.067
7553ZNF7LZE20THumanEsophagusESCC4.14e-021.44e-010.0662
7553ZNF7LZE24THumanEsophagusESCC6.53e-122.92e-010.0596
7553ZNF7P1T-EHumanEsophagusESCC1.36e-073.00e-010.0875
7553ZNF7P2T-EHumanEsophagusESCC3.50e-173.55e-010.1177
7553ZNF7P4T-EHumanEsophagusESCC2.71e-143.38e-010.1323
7553ZNF7P5T-EHumanEsophagusESCC1.05e-172.77e-010.1327
7553ZNF7P8T-EHumanEsophagusESCC2.17e-162.24e-010.0889
7553ZNF7P9T-EHumanEsophagusESCC8.50e-112.83e-010.1131
7553ZNF7P10T-EHumanEsophagusESCC9.85e-173.63e-010.116
7553ZNF7P11T-EHumanEsophagusESCC4.21e-185.88e-010.1426
7553ZNF7P12T-EHumanEsophagusESCC3.45e-315.73e-010.1122
7553ZNF7P15T-EHumanEsophagusESCC1.61e-184.03e-010.1149
7553ZNF7P16T-EHumanEsophagusESCC2.07e-487.68e-010.1153
7553ZNF7P17T-EHumanEsophagusESCC2.63e-062.98e-010.1278
7553ZNF7P20T-EHumanEsophagusESCC1.35e-152.88e-010.1124
7553ZNF7P21T-EHumanEsophagusESCC3.22e-203.98e-010.1617
7553ZNF7P22T-EHumanEsophagusESCC1.40e-092.37e-010.1236
7553ZNF7P23T-EHumanEsophagusESCC2.13e-214.84e-010.108
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00064179BreastPrecancerregulation of translation67/1080468/187234.71e-127.64e-1067
GO:000641714BreastIDCregulation of translation74/1434468/187231.67e-091.53e-0774
GO:004873214BreastIDCgland development64/1434436/187233.47e-071.74e-0564
GO:005067313BreastIDCepithelial cell proliferation60/1434437/187237.13e-062.15e-0460
GO:003235512BreastIDCresponse to estradiol27/1434141/187237.87e-062.35e-0427
GO:005067812BreastIDCregulation of epithelial cell proliferation54/1434381/187238.07e-062.39e-0454
GO:003359811BreastIDCmammary gland epithelial cell proliferation10/143426/187231.14e-053.08e-0410
GO:003410913BreastIDChomotypic cell-cell adhesion20/143490/187231.20e-053.17e-0420
GO:003087911BreastIDCmammary gland development23/1434137/187232.87e-044.37e-0323
GO:002240712BreastIDCregulation of cell-cell adhesion55/1434448/187233.43e-045.07e-0355
GO:005067911BreastIDCpositive regulation of epithelial cell proliferation29/1434207/187231.14e-031.24e-0229
GO:0034333BreastIDCadherens junction assembly5/143412/187231.31e-031.37e-025
GO:000183711BreastIDCepithelial to mesenchymal transition23/1434157/187231.97e-031.88e-0223
GO:00071625BreastIDCnegative regulation of cell adhesion37/1434303/187233.27e-032.75e-0237
GO:0033599BreastIDCregulation of mammary gland epithelial cell proliferation5/143415/187234.10e-033.25e-025
GO:00611804BreastIDCmammary gland epithelium development12/143467/187234.53e-033.49e-0212
GO:000641724BreastDCISregulation of translation72/1390468/187232.46e-092.17e-0772
GO:004873223BreastDCISgland development60/1390436/187232.50e-068.74e-0560
GO:003359821BreastDCISmammary gland epithelial cell proliferation10/139026/187238.68e-062.37e-0410
GO:003235521BreastDCISresponse to estradiol26/1390141/187231.34e-053.33e-0426
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZNF7SNVMissense_Mutationnovelc.1276T>Gp.Cys426Glyp.C426GP17097protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A8-A09M-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapypaclitaxelCR
ZNF7SNVMissense_Mutationrs200609680c.693N>Cp.Gln231Hisp.Q231HP17097protein_codingdeleterious(0)benign(0.276)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
ZNF7SNVMissense_Mutationrs548449450c.784N>Ap.Glu262Lysp.E262KP17097protein_codingtolerated(0.56)benign(0.003)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF7SNVMissense_Mutationnovelc.615N>Ap.Met205Ilep.M205IP17097protein_codingtolerated(0.24)benign(0)TCGA-LL-A8F5-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
ZNF7insertionNonsense_Mutationnovelc.1045_1046insGTTTCTGATTCTGAGGTCTGGTTp.Glu349GlyfsTer3p.E349Gfs*3P17097protein_codingTCGA-A7-A0CE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
ZNF7insertionIn_Frame_Insnovelc.486_487insTCTTGGCAGCTCTTCCAGCCTp.Asn162_Cys163insSerTrpGlnLeuPheGlnProp.N162_C163insSWQLFQPP17097protein_codingTCGA-A8-A06X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF7insertionNonsense_Mutationnovelc.1818_1819insTCACACTGGAGAAAAACCATTTAAATGTGATGAGTGTGGCAAAGGp.Tyr606_Leu607insSerHisTrpArgLysThrIleTerMetTerTerValTrpGlnArgp.Y606_L607insSHWRKTI*M**VWQRP17097protein_codingTCGA-A8-A095-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
ZNF7insertionFrame_Shift_Insnovelc.1111_1112insACAGGACTTTCCTCAGAATCCTGGCTTTGGAGACGTTTCTp.Arg371AsnfsTer68p.R371Nfs*68P17097protein_codingTCGA-A8-A097-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
ZNF7insertionIn_Frame_Insnovelc.435_436insAGTGAAp.Ser145_His146insSerGlup.S145_H146insSEP17097protein_codingTCGA-B6-A0RE-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZNF7insertionFrame_Shift_Insnovelc.437_438insAGGTAAAAAGTATGAAACCACTp.His146GlnfsTer24p.H146Qfs*24P17097protein_codingTCGA-B6-A0RE-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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