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Gene: ZNF699 |
Gene summary for ZNF699 |
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Gene information | Species | Human | Gene symbol | ZNF699 | Gene ID | 374879 |
Gene name | zinc finger protein 699 | |
Gene Alias | DEGCAGS | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q32M78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374879 | ZNF699 | HCC1 | Human | Liver | HCC | 2.40e-10 | 1.04e+00 | 0.5336 |
374879 | ZNF699 | HCC2 | Human | Liver | HCC | 8.06e-18 | 1.52e+00 | 0.5341 |
374879 | ZNF699 | HCC5 | Human | Liver | HCC | 2.17e-07 | 8.84e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF699 | SNV | Missense_Mutation | c.286N>T | p.Gly96Cys | p.G96C | Q32M78 | protein_coding | tolerated(0.11) | possibly_damaging(0.552) | TCGA-AR-A24S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD | |
ZNF699 | SNV | Missense_Mutation | c.824N>A | p.Gly275Glu | p.G275E | Q32M78 | protein_coding | tolerated(0.05) | benign(0.098) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF699 | SNV | Missense_Mutation | c.1165N>G | p.Lys389Glu | p.K389E | Q32M78 | protein_coding | deleterious(0.02) | possibly_damaging(0.57) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF699 | SNV | Missense_Mutation | c.733C>T | p.Pro245Ser | p.P245S | Q32M78 | protein_coding | tolerated(0.47) | benign(0.171) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF699 | SNV | Missense_Mutation | c.1694G>A | p.Gly565Glu | p.G565E | Q32M78 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
ZNF699 | SNV | Missense_Mutation | rs764662366 | c.896G>T | p.Arg299Ile | p.R299I | Q32M78 | protein_coding | deleterious(0) | possibly_damaging(0.506) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF699 | SNV | Missense_Mutation | novel | c.702T>G | p.Phe234Leu | p.F234L | Q32M78 | protein_coding | tolerated(0.64) | benign(0.01) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF699 | SNV | Missense_Mutation | rs776614133 | c.122G>T | p.Arg41Ile | p.R41I | Q32M78 | protein_coding | deleterious(0) | benign(0.38) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ZNF699 | SNV | Missense_Mutation | novel | c.1696N>G | p.Lys566Glu | p.K566E | Q32M78 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF699 | SNV | Missense_Mutation | novel | c.1317N>C | p.Lys439Asn | p.K439N | Q32M78 | protein_coding | deleterious(0.02) | possibly_damaging(0.82) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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