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Gene: ZNF695 |
Gene summary for ZNF695 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF695 | Gene ID | 57116 |
| Gene name | zinc finger protein 695 | |
| Gene Alias | SBZF3 | |
| Cytomap | 1q44 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8IW36 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57116 | ZNF695 | P2T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.79e-01 | 0.1177 |
| 57116 | ZNF695 | P12T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.01e-01 | 0.1122 |
| 57116 | ZNF695 | P16T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.35e-01 | 0.1153 |
| 57116 | ZNF695 | P21T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.18e-01 | 0.1617 |
| 57116 | ZNF695 | P22T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.95e-01 | 0.1236 |
| 57116 | ZNF695 | P28T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.21e-01 | 0.1149 |
| 57116 | ZNF695 | P36T-E | Human | Esophagus | ESCC | 1.57e-02 | 1.66e-01 | 0.1187 |
| 57116 | ZNF695 | P52T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.35e-02 | 0.1555 |
| 57116 | ZNF695 | P75T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.19e-01 | 0.1125 |
| 57116 | ZNF695 | P76T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.19e-01 | 0.1207 |
| 57116 | ZNF695 | P83T-E | Human | Esophagus | ESCC | 1.20e-10 | 3.81e-01 | 0.1738 |
| 57116 | ZNF695 | P91T-E | Human | Esophagus | ESCC | 4.81e-04 | 5.11e-01 | 0.1828 |
| 57116 | ZNF695 | P107T-E | Human | Esophagus | ESCC | 4.23e-24 | 5.59e-01 | 0.171 |
| 57116 | ZNF695 | P128T-E | Human | Esophagus | ESCC | 2.81e-07 | 3.08e-01 | 0.1241 |
| 57116 | ZNF695 | P130T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.40e-01 | 0.1676 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF695 | SNV | Missense_Mutation | c.1089N>C | p.Gln363His | p.Q363H | Q8IW36 | protein_coding | tolerated(0.49) | possibly_damaging(0.659) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
| ZNF695 | SNV | Missense_Mutation | c.490N>T | p.Gly164Cys | p.G164C | Q8IW36 | protein_coding | deleterious(0) | benign(0.243) | TCGA-C8-A138-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| ZNF695 | SNV | Missense_Mutation | c.861N>C | p.Lys287Asn | p.K287N | Q8IW36 | protein_coding | deleterious(0.02) | benign(0.07) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| ZNF695 | SNV | Missense_Mutation | c.1043N>C | p.Gly348Ala | p.G348A | Q8IW36 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| ZNF695 | SNV | Missense_Mutation | c.179N>G | p.Ser60Cys | p.S60C | Q8IW36 | protein_coding | deleterious(0.03) | possibly_damaging(0.7) | TCGA-UU-A93S-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
| ZNF695 | SNV | Missense_Mutation | novel | c.611G>C | p.Arg204Thr | p.R204T | Q8IW36 | protein_coding | tolerated(0.09) | benign(0.37) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF695 | SNV | Missense_Mutation | c.562N>C | p.Glu188Gln | p.E188Q | Q8IW36 | protein_coding | deleterious(0.05) | benign(0.015) | TCGA-AA-3712-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
| ZNF695 | SNV | Missense_Mutation | c.380N>G | p.Asp127Gly | p.D127G | Q8IW36 | protein_coding | tolerated(1) | benign(0.097) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF695 | SNV | Missense_Mutation | c.1184T>G | p.Leu395Arg | p.L395R | Q8IW36 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
| ZNF695 | SNV | Missense_Mutation | rs201180849 | c.175A>G | p.Met59Val | p.M59V | Q8IW36 | protein_coding | tolerated(1) | benign(0.019) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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