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Gene: ZNF682 |
Gene summary for ZNF682 |
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Gene information | Species | Human | Gene symbol | ZNF682 | Gene ID | 91120 |
Gene name | zinc finger protein 682 | |
Gene Alias | BC39498_3 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KUX2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91120 | ZNF682 | HCC1_Meng | Human | Liver | HCC | 5.81e-27 | 8.51e-02 | 0.0246 |
91120 | ZNF682 | HCC1 | Human | Liver | HCC | 1.59e-02 | 1.29e+00 | 0.5336 |
91120 | ZNF682 | HCC2 | Human | Liver | HCC | 3.46e-05 | 1.74e+00 | 0.5341 |
91120 | ZNF682 | HCC5 | Human | Liver | HCC | 1.22e-09 | 2.62e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF682 | SNV | Missense_Mutation | rs368709233 | c.1355N>A | p.Arg452His | p.R452H | O95780 | protein_coding | deleterious(0.02) | benign(0.009) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD |
ZNF682 | SNV | Missense_Mutation | c.43N>G | p.Leu15Val | p.L15V | O95780 | protein_coding | tolerated(0.16) | probably_damaging(0.909) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF682 | SNV | Missense_Mutation | c.39C>A | p.Phe13Leu | p.F13L | O95780 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ZNF682 | SNV | Missense_Mutation | rs776964289 | c.746N>T | p.Arg249Ile | p.R249I | O95780 | protein_coding | tolerated(0.4) | benign(0.051) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZNF682 | SNV | Missense_Mutation | c.380N>C | p.Lys127Thr | p.K127T | O95780 | protein_coding | deleterious(0.02) | benign(0.086) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF682 | SNV | Missense_Mutation | c.1044N>C | p.Lys348Asn | p.K348N | O95780 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF682 | SNV | Missense_Mutation | c.1067N>A | p.Leu356His | p.L356H | O95780 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6932-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF682 | SNV | Missense_Mutation | c.1129N>A | p.Val377Ile | p.V377I | O95780 | protein_coding | deleterious(0.03) | benign(0.326) | TCGA-G4-6299-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
ZNF682 | SNV | Missense_Mutation | c.233C>T | p.Ser78Phe | p.S78F | O95780 | protein_coding | tolerated(0.05) | benign(0.096) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF682 | SNV | Missense_Mutation | novel | c.499C>T | p.His167Tyr | p.H167Y | O95780 | protein_coding | tolerated(0.1) | possibly_damaging(0.734) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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