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Gene: ZNF680 |
Gene summary for ZNF680 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF680 | Gene ID | 340252 |
Gene name | zinc finger protein 680 | |
Gene Alias | ZNF680 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NEM1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
340252 | ZNF680 | LZE4T | Human | Esophagus | ESCC | 4.24e-03 | 2.14e-01 | 0.0811 |
340252 | ZNF680 | LZE20T | Human | Esophagus | ESCC | 2.59e-02 | 1.25e-01 | 0.0662 |
340252 | ZNF680 | LZE24T | Human | Esophagus | ESCC | 4.55e-10 | 2.31e-01 | 0.0596 |
340252 | ZNF680 | P1T-E | Human | Esophagus | ESCC | 3.00e-05 | 3.20e-01 | 0.0875 |
340252 | ZNF680 | P2T-E | Human | Esophagus | ESCC | 5.32e-15 | 3.05e-01 | 0.1177 |
340252 | ZNF680 | P4T-E | Human | Esophagus | ESCC | 1.26e-14 | 3.70e-01 | 0.1323 |
340252 | ZNF680 | P5T-E | Human | Esophagus | ESCC | 5.90e-10 | 1.88e-01 | 0.1327 |
340252 | ZNF680 | P8T-E | Human | Esophagus | ESCC | 2.20e-23 | 3.51e-01 | 0.0889 |
340252 | ZNF680 | P10T-E | Human | Esophagus | ESCC | 5.68e-31 | 4.99e-01 | 0.116 |
340252 | ZNF680 | P12T-E | Human | Esophagus | ESCC | 6.11e-30 | 5.85e-01 | 0.1122 |
340252 | ZNF680 | P15T-E | Human | Esophagus | ESCC | 2.82e-09 | 2.67e-01 | 0.1149 |
340252 | ZNF680 | P16T-E | Human | Esophagus | ESCC | 6.89e-16 | 3.24e-01 | 0.1153 |
340252 | ZNF680 | P20T-E | Human | Esophagus | ESCC | 6.23e-05 | 1.62e-01 | 0.1124 |
340252 | ZNF680 | P21T-E | Human | Esophagus | ESCC | 1.22e-08 | 9.82e-02 | 0.1617 |
340252 | ZNF680 | P22T-E | Human | Esophagus | ESCC | 7.28e-18 | 3.22e-01 | 0.1236 |
340252 | ZNF680 | P24T-E | Human | Esophagus | ESCC | 2.81e-02 | 1.21e-01 | 0.1287 |
340252 | ZNF680 | P26T-E | Human | Esophagus | ESCC | 1.76e-08 | 1.48e-01 | 0.1276 |
340252 | ZNF680 | P27T-E | Human | Esophagus | ESCC | 9.87e-18 | 3.39e-01 | 0.1055 |
340252 | ZNF680 | P28T-E | Human | Esophagus | ESCC | 3.43e-28 | 5.01e-01 | 0.1149 |
340252 | ZNF680 | P30T-E | Human | Esophagus | ESCC | 3.24e-15 | 4.66e-01 | 0.137 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF680 | SNV | Missense_Mutation | novel | c.968A>C | p.Lys323Thr | p.K323T | Q8NEM1 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | novel | c.490C>A | p.His164Asn | p.H164N | Q8NEM1 | protein_coding | tolerated(0.13) | benign(0.065) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | rs376623323 | c.1502G>A | p.Arg501Gln | p.R501Q | Q8NEM1 | protein_coding | tolerated(1) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF680 | SNV | Missense_Mutation | novel | c.899N>G | p.His300Arg | p.H300R | Q8NEM1 | protein_coding | deleterious(0.01) | benign(0.359) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF680 | SNV | Missense_Mutation | novel | c.898N>G | p.His300Asp | p.H300D | Q8NEM1 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF680 | SNV | Missense_Mutation | novel | c.920C>T | p.Ala307Val | p.A307V | Q8NEM1 | protein_coding | deleterious(0) | benign(0.058) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | novel | c.1523A>T | p.His508Leu | p.H508L | Q8NEM1 | protein_coding | deleterious(0) | possibly_damaging(0.495) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF680 | SNV | Missense_Mutation | rs147253391 | c.178N>T | p.His60Tyr | p.H60Y | Q8NEM1 | protein_coding | deleterious(0.03) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | c.391G>A | p.Glu131Lys | p.E131K | Q8NEM1 | protein_coding | tolerated(0.05) | benign(0.108) | TCGA-A6-5660-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
ZNF680 | SNV | Missense_Mutation | c.1261N>T | p.Leu421Phe | p.L421F | Q8NEM1 | protein_coding | deleterious(0.04) | benign(0.193) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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