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Gene: ZNF664 |
Gene summary for ZNF664 |
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Gene information | Species | Human | Gene symbol | ZNF664 | Gene ID | 144348 |
Gene name | zinc finger protein 664 | |
Gene Alias | ZFOC1 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RBR7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
144348 | ZNF664 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.84e-04 | 1.20e-01 | 0.0155 |
144348 | ZNF664 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.88e-04 | 1.68e-01 | -0.1808 |
144348 | ZNF664 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.24e-04 | 2.29e-01 | -0.0811 |
144348 | ZNF664 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.38e-10 | 2.95e-01 | -0.1088 |
144348 | ZNF664 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.18e-22 | 4.08e-01 | -0.1954 |
144348 | ZNF664 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 5.02e-01 | -0.2602 |
144348 | ZNF664 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.23e-03 | 1.46e-01 | -0.1526 |
144348 | ZNF664 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.25e-05 | 1.52e-01 | -0.1464 |
144348 | ZNF664 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.36e-06 | 1.57e-01 | -0.1001 |
144348 | ZNF664 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.21e-08 | 2.41e-01 | -0.059 |
144348 | ZNF664 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 3.53e-01 | -0.1706 |
144348 | ZNF664 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.95e-01 | -0.0179 |
144348 | ZNF664 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-10 | 2.42e-01 | 0.096 |
144348 | ZNF664 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.49e-06 | 3.04e-01 | 0.0528 |
144348 | ZNF664 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 3.07e-01 | 0.0131 |
144348 | ZNF664 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.07e-13 | 6.43e-01 | 0.0171 |
144348 | ZNF664 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.02e-03 | 1.51e-01 | 0.0338 |
144348 | ZNF664 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.46e-07 | 1.63e-01 | 0.0674 |
144348 | ZNF664 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.45e-04 | 4.12e-01 | -0.0124 |
144348 | ZNF664 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.37e-04 | 1.67e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF664 | SNV | Missense_Mutation | novel | c.82N>A | p.Glu28Lys | p.E28K | Q8N3J9 | protein_coding | deleterious(0.04) | benign(0.364) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ZNF664 | SNV | Missense_Mutation | c.556N>A | p.Leu186Ile | p.L186I | Q8N3J9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF664 | SNV | Missense_Mutation | c.656N>T | p.Arg219Ile | p.R219I | Q8N3J9 | protein_coding | tolerated(0.05) | possibly_damaging(0.802) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF664 | SNV | Missense_Mutation | c.656N>A | p.Arg219Lys | p.R219K | Q8N3J9 | protein_coding | deleterious(0.04) | possibly_damaging(0.726) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF664 | SNV | Missense_Mutation | c.36N>A | p.Phe12Leu | p.F12L | Q8N3J9 | protein_coding | deleterious(0.04) | possibly_damaging(0.703) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF664 | SNV | Missense_Mutation | novel | c.718A>G | p.Thr240Ala | p.T240A | Q8N3J9 | protein_coding | tolerated(0.05) | benign(0.001) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF664 | SNV | Missense_Mutation | novel | c.286N>C | p.Phe96Leu | p.F96L | Q8N3J9 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-CM-6677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF664 | SNV | Missense_Mutation | c.619G>T | p.Ala207Ser | p.A207S | Q8N3J9 | protein_coding | tolerated(0.19) | benign(0.058) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF664 | SNV | Missense_Mutation | novel | c.52N>A | p.Leu18Ile | p.L18I | Q8N3J9 | protein_coding | deleterious(0) | benign(0.427) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF664 | SNV | Missense_Mutation | rs767125869 | c.551N>T | p.Ser184Leu | p.S184L | Q8N3J9 | protein_coding | deleterious(0.01) | benign(0.319) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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