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Gene: ZNF662 |
Gene summary for ZNF662 |
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Gene information | Species | Human | Gene symbol | ZNF662 | Gene ID | 389114 |
Gene name | zinc finger protein 662 | |
Gene Alias | ZNF662 | |
Cytomap | 3p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZS27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389114 | ZNF662 | HCC1 | Human | Liver | HCC | 2.20e-11 | 1.32e+00 | 0.5336 |
389114 | ZNF662 | HCC2 | Human | Liver | HCC | 3.44e-15 | 1.83e+00 | 0.5341 |
389114 | ZNF662 | HCC5 | Human | Liver | HCC | 2.00e-12 | 1.45e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF662 | SNV | Missense_Mutation | c.535G>A | p.Asp179Asn | p.D179N | Q6ZS27 | protein_coding | tolerated(0.27) | benign(0.031) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
ZNF662 | SNV | Missense_Mutation | rs150652820 | c.872G>A | p.Arg291His | p.R291H | Q6ZS27 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
ZNF662 | SNV | Missense_Mutation | c.241N>G | p.Leu81Val | p.L81V | Q6ZS27 | protein_coding | tolerated(0.44) | benign(0.237) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF662 | SNV | Missense_Mutation | c.434N>A | p.Gly145Glu | p.G145E | Q6ZS27 | protein_coding | tolerated(0.47) | benign(0.217) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
ZNF662 | SNV | Missense_Mutation | rs771672866 | c.1199A>G | p.His400Arg | p.H400R | Q6ZS27 | protein_coding | tolerated(0.75) | benign(0.015) | TCGA-EW-A6SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tch | SD |
ZNF662 | SNV | Missense_Mutation | rs754625908 | c.145G>A | p.Gly49Ser | p.G49S | Q6ZS27 | protein_coding | tolerated(0.98) | benign(0.009) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF662 | SNV | Missense_Mutation | rs754424406 | c.1210N>T | p.His404Tyr | p.H404Y | Q6ZS27 | protein_coding | deleterious(0.03) | possibly_damaging(0.568) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | rs781421409 | c.904T>C | p.Phe302Leu | p.F302L | Q6ZS27 | protein_coding | deleterious(0.01) | possibly_damaging(0.634) | TCGA-3L-AA1B-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | c.1208N>A | p.Arg403Gln | p.R403Q | Q6ZS27 | protein_coding | tolerated(0.93) | benign(0.003) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | c.286C>A | p.Pro96Thr | p.P96T | Q6ZS27 | protein_coding | deleterious(0.05) | benign(0.021) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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