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Gene: ZNF641 |
Gene summary for ZNF641 |
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Gene information | Species | Human | Gene symbol | ZNF641 | Gene ID | 121274 |
Gene name | zinc finger protein 641 | |
Gene Alias | ZNF641 | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96N77 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121274 | ZNF641 | male-WTA | Human | Thyroid | PTC | 3.58e-09 | 9.83e-02 | 0.1037 |
121274 | ZNF641 | PTC04 | Human | Thyroid | PTC | 5.02e-07 | 1.29e-01 | 0.1927 |
121274 | ZNF641 | PTC06 | Human | Thyroid | PTC | 6.79e-13 | 2.17e-01 | 0.2057 |
121274 | ZNF641 | PTC07 | Human | Thyroid | PTC | 3.50e-08 | 1.50e-01 | 0.2044 |
121274 | ZNF641 | ATC13 | Human | Thyroid | ATC | 1.79e-27 | 5.16e-01 | 0.34 |
121274 | ZNF641 | ATC5 | Human | Thyroid | ATC | 3.03e-25 | 5.58e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF641 | SNV | Missense_Mutation | c.1017N>C | p.Gln339His | p.Q339H | Q96N77 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF641 | SNV | Missense_Mutation | c.250G>C | p.Ala84Pro | p.A84P | Q96N77 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-B6-A0WY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZNF641 | insertion | Frame_Shift_Ins | novel | c.450_451insGTTTTATTACT | p.Phe151ValfsTer16 | p.F151Vfs*16 | Q96N77 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ZNF641 | deletion | Frame_Shift_Del | novel | c.82delN | p.Glu28AsnfsTer3 | p.E28Nfs*3 | Q96N77 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNF641 | SNV | Missense_Mutation | novel | c.1028N>G | p.Ala343Gly | p.A343G | Q96N77 | protein_coding | tolerated(0.11) | benign(0.133) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF641 | SNV | Missense_Mutation | novel | c.305N>T | p.Ala102Val | p.A102V | Q96N77 | protein_coding | deleterious(0.03) | possibly_damaging(0.626) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ZNF641 | SNV | Missense_Mutation | c.1253N>G | p.His418Arg | p.H418R | Q96N77 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF641 | SNV | Missense_Mutation | novel | c.203A>G | p.Glu68Gly | p.E68G | Q96N77 | protein_coding | deleterious(0) | benign(0.007) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF641 | SNV | Missense_Mutation | novel | c.905G>T | p.Gly302Val | p.G302V | Q96N77 | protein_coding | tolerated(0.25) | possibly_damaging(0.478) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF641 | SNV | Missense_Mutation | c.170N>A | p.Pro57His | p.P57H | Q96N77 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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