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Gene: ZNF621 |
Gene summary for ZNF621 |
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Gene information | Species | Human | Gene symbol | ZNF621 | Gene ID | 285268 |
Gene name | zinc finger protein 621 | |
Gene Alias | ZNF621 | |
Cytomap | 3p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZSS3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285268 | ZNF621 | HCC1_Meng | Human | Liver | HCC | 9.13e-14 | 3.67e-03 | 0.0246 |
285268 | ZNF621 | HCC2_Meng | Human | Liver | HCC | 1.69e-04 | 2.05e-02 | 0.0107 |
285268 | ZNF621 | HCC1 | Human | Liver | HCC | 5.86e-07 | 2.29e+00 | 0.5336 |
285268 | ZNF621 | HCC2 | Human | Liver | HCC | 1.12e-23 | 3.81e+00 | 0.5341 |
285268 | ZNF621 | HCC5 | Human | Liver | HCC | 3.75e-08 | 2.11e+00 | 0.4932 |
285268 | ZNF621 | S016 | Human | Liver | HCC | 1.11e-03 | 2.61e-01 | 0.2243 |
285268 | ZNF621 | S028 | Human | Liver | HCC | 6.75e-15 | 7.03e-01 | 0.2503 |
285268 | ZNF621 | S029 | Human | Liver | HCC | 3.60e-10 | 5.32e-01 | 0.2581 |
285268 | ZNF621 | male-WTA | Human | Thyroid | PTC | 5.91e-10 | 1.07e-01 | 0.1037 |
285268 | ZNF621 | PTC01 | Human | Thyroid | PTC | 5.32e-03 | 7.14e-02 | 0.1899 |
285268 | ZNF621 | PTC03 | Human | Thyroid | PTC | 1.35e-04 | 2.39e-01 | 0.1784 |
285268 | ZNF621 | PTC04 | Human | Thyroid | PTC | 1.21e-16 | 1.78e-01 | 0.1927 |
285268 | ZNF621 | PTC05 | Human | Thyroid | PTC | 1.05e-08 | 2.84e-01 | 0.2065 |
285268 | ZNF621 | PTC06 | Human | Thyroid | PTC | 3.84e-16 | 3.42e-01 | 0.2057 |
285268 | ZNF621 | PTC07 | Human | Thyroid | PTC | 9.05e-18 | 2.03e-01 | 0.2044 |
285268 | ZNF621 | ATC12 | Human | Thyroid | ATC | 2.35e-06 | 1.18e-01 | 0.34 |
285268 | ZNF621 | ATC13 | Human | Thyroid | ATC | 5.82e-24 | 3.96e-01 | 0.34 |
285268 | ZNF621 | ATC1 | Human | Thyroid | ATC | 8.56e-03 | 1.40e-01 | 0.2878 |
285268 | ZNF621 | ATC2 | Human | Thyroid | ATC | 1.80e-12 | 6.29e-01 | 0.34 |
285268 | ZNF621 | ATC3 | Human | Thyroid | ATC | 5.52e-09 | 3.67e-01 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF621 | SNV | Missense_Mutation | novel | c.1077N>T | p.Gln359His | p.Q359H | Q6ZSS3 | protein_coding | tolerated(0.26) | benign(0) | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF621 | SNV | Missense_Mutation | rs769362004 | c.92N>T | p.Ala31Val | p.A31V | Q6ZSS3 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF621 | SNV | Missense_Mutation | c.440G>A | p.Gly147Glu | p.G147E | Q6ZSS3 | protein_coding | tolerated(0.06) | probably_damaging(0.986) | TCGA-BH-A0DX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
ZNF621 | SNV | Missense_Mutation | rs374160688 | c.110N>A | p.Gly37Glu | p.G37E | Q6ZSS3 | protein_coding | deleterious(0) | benign(0.042) | TCGA-DS-A7WH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF621 | SNV | Missense_Mutation | c.513N>C | p.Met171Ile | p.M171I | Q6ZSS3 | protein_coding | tolerated(0.21) | benign(0.01) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF621 | SNV | Missense_Mutation | novel | c.1194N>G | p.Phe398Leu | p.F398L | Q6ZSS3 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF621 | SNV | Missense_Mutation | c.932N>T | p.Arg311Ile | p.R311I | Q6ZSS3 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF621 | SNV | Missense_Mutation | c.1001N>G | p.Phe334Cys | p.F334C | Q6ZSS3 | protein_coding | deleterious(0) | benign(0.321) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF621 | SNV | Missense_Mutation | novel | c.1004T>C | p.Val335Ala | p.V335A | Q6ZSS3 | protein_coding | tolerated(0.08) | benign(0.179) | TCGA-AZ-4323-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
ZNF621 | SNV | Missense_Mutation | c.115N>T | p.Val39Leu | p.V39L | Q6ZSS3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-5344-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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