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Gene: ZNF608 |
Gene summary for ZNF608 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF608 | Gene ID | 57507 |
Gene name | zinc finger protein 608 | |
Gene Alias | NY-REN-36 | |
Cytomap | 5q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B3KPE6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57507 | ZNF608 | P2T-E | Human | Esophagus | ESCC | 2.37e-07 | 7.21e-02 | 0.1177 |
57507 | ZNF608 | P4T-E | Human | Esophagus | ESCC | 1.73e-03 | 8.14e-02 | 0.1323 |
57507 | ZNF608 | P8T-E | Human | Esophagus | ESCC | 2.21e-09 | 2.31e-01 | 0.0889 |
57507 | ZNF608 | P10T-E | Human | Esophagus | ESCC | 2.46e-05 | 5.25e-02 | 0.116 |
57507 | ZNF608 | P11T-E | Human | Esophagus | ESCC | 9.11e-03 | 1.11e-01 | 0.1426 |
57507 | ZNF608 | P12T-E | Human | Esophagus | ESCC | 4.44e-16 | 3.28e-01 | 0.1122 |
57507 | ZNF608 | P15T-E | Human | Esophagus | ESCC | 8.96e-09 | 1.60e-01 | 0.1149 |
57507 | ZNF608 | P16T-E | Human | Esophagus | ESCC | 3.82e-04 | 3.01e-02 | 0.1153 |
57507 | ZNF608 | P21T-E | Human | Esophagus | ESCC | 7.49e-08 | 1.26e-01 | 0.1617 |
57507 | ZNF608 | P24T-E | Human | Esophagus | ESCC | 1.78e-04 | 4.43e-02 | 0.1287 |
57507 | ZNF608 | P26T-E | Human | Esophagus | ESCC | 1.81e-14 | 2.08e-01 | 0.1276 |
57507 | ZNF608 | P27T-E | Human | Esophagus | ESCC | 1.45e-15 | 1.60e-01 | 0.1055 |
57507 | ZNF608 | P28T-E | Human | Esophagus | ESCC | 1.13e-05 | 9.20e-02 | 0.1149 |
57507 | ZNF608 | P32T-E | Human | Esophagus | ESCC | 1.39e-13 | 1.22e-01 | 0.1666 |
57507 | ZNF608 | P36T-E | Human | Esophagus | ESCC | 1.41e-03 | 2.07e-01 | 0.1187 |
57507 | ZNF608 | P40T-E | Human | Esophagus | ESCC | 1.26e-05 | 1.22e-01 | 0.109 |
57507 | ZNF608 | P48T-E | Human | Esophagus | ESCC | 1.53e-02 | 4.47e-02 | 0.0959 |
57507 | ZNF608 | P52T-E | Human | Esophagus | ESCC | 6.33e-11 | 5.29e-02 | 0.1555 |
57507 | ZNF608 | P54T-E | Human | Esophagus | ESCC | 2.60e-05 | 7.49e-02 | 0.0975 |
57507 | ZNF608 | P57T-E | Human | Esophagus | ESCC | 2.53e-10 | 1.51e-01 | 0.0926 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF608 | SNV | Missense_Mutation | c.4519N>G | p.Pro1507Ala | p.P1507A | Q9ULD9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF608 | SNV | Missense_Mutation | rs149693964 | c.3947N>A | p.Arg1316Gln | p.R1316Q | Q9ULD9 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | novel | c.3305N>T | p.Arg1102Ile | p.R1102I | Q9ULD9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | novel | c.329N>C | p.Lys110Thr | p.K110T | Q9ULD9 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | c.272C>T | p.Ser91Phe | p.S91F | Q9ULD9 | protein_coding | deleterious(0) | possibly_damaging(0.66) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF608 | SNV | Missense_Mutation | novel | c.2387N>T | p.Gly796Val | p.G796V | Q9ULD9 | protein_coding | tolerated(0.15) | probably_damaging(0.988) | TCGA-B6-A40B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | c.4447N>G | p.Gln1483Glu | p.Q1483E | Q9ULD9 | protein_coding | tolerated(0.1) | possibly_damaging(0.647) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZNF608 | SNV | Missense_Mutation | novel | c.3281T>A | p.Leu1094Gln | p.L1094Q | Q9ULD9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A8FY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | rs374429838 | c.3449N>T | p.Ser1150Leu | p.S1150L | Q9ULD9 | protein_coding | tolerated(0.07) | benign(0.014) | TCGA-E9-A226-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
ZNF608 | deletion | In_Frame_Del | novel | c.198_215delNNNNNNNNNNNNNNNNNN | p.Gly67_Gly72del | p.G67_G72del | Q9ULD9 | protein_coding | TCGA-A2-A3XV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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