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Gene: ZNF595 |
Gene summary for ZNF595 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF595 | Gene ID | 152687 |
| Gene name | zinc finger protein 595 | |
| Gene Alias | ZNF595 | |
| Cytomap | 4p16.3 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A075B7G4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 152687 | ZNF595 | P2T-E | Human | Esophagus | ESCC | 4.14e-14 | 3.08e-01 | 0.1177 |
| 152687 | ZNF595 | P4T-E | Human | Esophagus | ESCC | 1.58e-04 | 1.49e-01 | 0.1323 |
| 152687 | ZNF595 | P5T-E | Human | Esophagus | ESCC | 2.74e-03 | 2.48e-02 | 0.1327 |
| 152687 | ZNF595 | P8T-E | Human | Esophagus | ESCC | 9.77e-13 | 2.03e-01 | 0.0889 |
| 152687 | ZNF595 | P10T-E | Human | Esophagus | ESCC | 4.82e-14 | 1.04e-01 | 0.116 |
| 152687 | ZNF595 | P11T-E | Human | Esophagus | ESCC | 8.82e-04 | 2.45e-01 | 0.1426 |
| 152687 | ZNF595 | P12T-E | Human | Esophagus | ESCC | 2.98e-06 | 1.50e-01 | 0.1122 |
| 152687 | ZNF595 | P15T-E | Human | Esophagus | ESCC | 4.21e-09 | 1.76e-01 | 0.1149 |
| 152687 | ZNF595 | P16T-E | Human | Esophagus | ESCC | 6.60e-10 | 2.01e-01 | 0.1153 |
| 152687 | ZNF595 | P20T-E | Human | Esophagus | ESCC | 1.22e-46 | 9.51e-01 | 0.1124 |
| 152687 | ZNF595 | P21T-E | Human | Esophagus | ESCC | 4.36e-05 | 4.61e-02 | 0.1617 |
| 152687 | ZNF595 | P22T-E | Human | Esophagus | ESCC | 4.64e-21 | 3.61e-01 | 0.1236 |
| 152687 | ZNF595 | P23T-E | Human | Esophagus | ESCC | 4.07e-02 | 6.69e-02 | 0.108 |
| 152687 | ZNF595 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 2.94e-02 | 0.1287 |
| 152687 | ZNF595 | P27T-E | Human | Esophagus | ESCC | 8.04e-19 | 1.04e-01 | 0.1055 |
| 152687 | ZNF595 | P28T-E | Human | Esophagus | ESCC | 1.37e-24 | 4.22e-01 | 0.1149 |
| 152687 | ZNF595 | P31T-E | Human | Esophagus | ESCC | 3.90e-08 | 1.11e-01 | 0.1251 |
| 152687 | ZNF595 | P32T-E | Human | Esophagus | ESCC | 2.17e-09 | 1.14e-01 | 0.1666 |
| 152687 | ZNF595 | P37T-E | Human | Esophagus | ESCC | 1.95e-05 | 9.75e-02 | 0.1371 |
| 152687 | ZNF595 | P39T-E | Human | Esophagus | ESCC | 4.48e-05 | 4.85e-02 | 0.0894 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF595 | M1MAC | Cervix | ADJ | VNN3,ERO1B,KCNJ15, etc. | 1.36e-01 |  |
| ZNF595 | PLA | Cervix | ADJ | VNN3,ERO1B,KCNJ15, etc. | 2.57e-02 | |
| ZNF595 | TFH | Cervix | N_HPV | VNN3,ERO1B,KCNJ15, etc. | 8.89e-03 |  |
| ZNF595 | MAIT | Cervix | N_HPV | VNN3,ERO1B,KCNJ15, etc. | 9.06e-03 | |
| ZNF595 | BMEM | Colorectum | CRC | SPATA20,ABCB1,UEVLD, etc. | 4.29e-02 |  |
| ZNF595 | ILC | Colorectum | Healthy | SPATA20,ABCB1,UEVLD, etc. | 5.14e-02 |  |
| ZNF595 | END | Colorectum | MSI-H | NR1D2,AGBL4,CELSR1, etc. | 5.82e-01 |  |
| ZNF595 | ECC | Skin | AK | ZNF141,KDM7A-DT,GPX2, etc. | 1.11e-01 |  |
| ZNF595 | PIL | Skin | cSCC | ZNF141,KDM7A-DT,GPX2, etc. | 2.03e-02 |  |
| ZNF595 | FIB | Skin | ADJ | TOE1,PJA1,CWC22, etc. | 2.45e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF595 | SNV | Missense_Mutation | novel | c.1657N>A | p.Glu553Lys | p.E553K | protein_coding | tolerated(1) | benign(0.015) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ZNF595 | SNV | Missense_Mutation | c.127N>A | p.Leu43Met | p.L43M | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
| ZNF595 | SNV | Missense_Mutation | novel | c.1177G>C | p.Glu393Gln | p.E393Q | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF595 | SNV | Missense_Mutation | c.121N>T | p.Val41Phe | p.V41F | protein_coding | deleterious(0.02) | possibly_damaging(0.801) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| ZNF595 | SNV | Missense_Mutation | novel | c.1273A>G | p.Thr425Ala | p.T425A | protein_coding | deleterious(0) | benign(0.023) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZNF595 | SNV | Missense_Mutation | novel | c.1856N>G | p.Ser619Cys | p.S619C | protein_coding | deleterious(0) | benign(0.327) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZNF595 | SNV | Missense_Mutation | c.95N>C | p.Val32Ala | p.V32A | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| ZNF595 | SNV | Missense_Mutation | novel | c.1024T>C | p.Cys342Arg | p.C342R | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF595 | SNV | Missense_Mutation | novel | c.60N>G | p.Cys20Trp | p.C20W | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3972-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
| ZNF595 | SNV | Missense_Mutation | novel | c.1331N>T | p.Arg444Ile | p.R444I | protein_coding | tolerated(0.37) | possibly_damaging(0.776) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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