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Gene: ZNF592 |
Gene summary for ZNF592 |
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Gene information | Species | Human | Gene symbol | ZNF592 | Gene ID | 9640 |
Gene name | zinc finger protein 592 | |
Gene Alias | CAMOS | |
Cytomap | 15q25.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q92610 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9640 | ZNF592 | LZE4T | Human | Esophagus | ESCC | 6.49e-08 | 2.11e-01 | 0.0811 |
9640 | ZNF592 | LZE7T | Human | Esophagus | ESCC | 8.49e-05 | 3.62e-01 | 0.0667 |
9640 | ZNF592 | LZE24T | Human | Esophagus | ESCC | 1.60e-05 | 1.91e-01 | 0.0596 |
9640 | ZNF592 | P2T-E | Human | Esophagus | ESCC | 7.08e-04 | 1.15e-01 | 0.1177 |
9640 | ZNF592 | P4T-E | Human | Esophagus | ESCC | 4.58e-06 | 1.35e-01 | 0.1323 |
9640 | ZNF592 | P5T-E | Human | Esophagus | ESCC | 2.94e-05 | 5.19e-02 | 0.1327 |
9640 | ZNF592 | P8T-E | Human | Esophagus | ESCC | 3.39e-10 | 2.31e-01 | 0.0889 |
9640 | ZNF592 | P9T-E | Human | Esophagus | ESCC | 2.08e-08 | 2.00e-01 | 0.1131 |
9640 | ZNF592 | P10T-E | Human | Esophagus | ESCC | 3.37e-11 | 2.27e-01 | 0.116 |
9640 | ZNF592 | P12T-E | Human | Esophagus | ESCC | 4.14e-11 | 2.00e-01 | 0.1122 |
9640 | ZNF592 | P15T-E | Human | Esophagus | ESCC | 1.14e-17 | 3.98e-01 | 0.1149 |
9640 | ZNF592 | P16T-E | Human | Esophagus | ESCC | 8.56e-08 | 1.57e-01 | 0.1153 |
9640 | ZNF592 | P20T-E | Human | Esophagus | ESCC | 5.05e-04 | 8.00e-02 | 0.1124 |
9640 | ZNF592 | P21T-E | Human | Esophagus | ESCC | 4.21e-02 | 4.83e-02 | 0.1617 |
9640 | ZNF592 | P22T-E | Human | Esophagus | ESCC | 3.91e-03 | 1.02e-01 | 0.1236 |
9640 | ZNF592 | P23T-E | Human | Esophagus | ESCC | 1.92e-15 | 3.22e-01 | 0.108 |
9640 | ZNF592 | P24T-E | Human | Esophagus | ESCC | 1.86e-02 | 5.35e-02 | 0.1287 |
9640 | ZNF592 | P26T-E | Human | Esophagus | ESCC | 1.42e-09 | 1.78e-01 | 0.1276 |
9640 | ZNF592 | P27T-E | Human | Esophagus | ESCC | 4.11e-06 | 9.20e-02 | 0.1055 |
9640 | ZNF592 | P28T-E | Human | Esophagus | ESCC | 2.69e-14 | 2.57e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF592 | SNV | Missense_Mutation | novel | c.1082C>T | p.Ser361Leu | p.S361L | Q92610 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ZNF592 | SNV | Missense_Mutation | c.34N>A | p.Leu12Ile | p.L12I | Q92610 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
ZNF592 | SNV | Missense_Mutation | c.1201C>T | p.Pro401Ser | p.P401S | Q92610 | protein_coding | tolerated(0.89) | benign(0.053) | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF592 | SNV | Missense_Mutation | c.832C>T | p.His278Tyr | p.H278Y | Q92610 | protein_coding | tolerated(0.13) | possibly_damaging(0.852) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF592 | SNV | Missense_Mutation | novel | c.1260G>T | p.Glu420Asp | p.E420D | Q92610 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF592 | SNV | Missense_Mutation | rs201965611 | c.2704N>T | p.Val902Leu | p.V902L | Q92610 | protein_coding | tolerated(0.85) | benign(0) | TCGA-B6-A0RN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF592 | SNV | Missense_Mutation | novel | c.1052G>A | p.Ser351Asn | p.S351N | Q92610 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ZNF592 | SNV | Missense_Mutation | c.2483N>G | p.Lys828Arg | p.K828R | Q92610 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
ZNF592 | SNV | Missense_Mutation | rs376104089 | c.2332N>T | p.Arg778Cys | p.R778C | Q92610 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A22B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZNF592 | insertion | Frame_Shift_Ins | novel | c.948_949insTCCTGTCATAGTATGTGGGGTTCTGCATGGGTGTGCT | p.Glu317SerfsTer13 | p.E317Sfs*13 | Q92610 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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