Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZNF580

Gene summary for ZNF580

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZNF580

Gene ID

51157

Gene namezinc finger protein 580
Gene AliasZNF580
Cytomap19q13.42
Gene Typeprotein-coding
GO ID

GO:0000302

UniProtAcc

Q9UK33


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51157ZNF580LZE4THumanEsophagusESCC3.96e-103.77e-010.0811
51157ZNF580LZE5THumanEsophagusESCC3.43e-023.00e-010.0514
51157ZNF580LZE20THumanEsophagusESCC4.30e-042.63e-010.0662
51157ZNF580LZE24THumanEsophagusESCC7.90e-235.14e-010.0596
51157ZNF580P1T-EHumanEsophagusESCC2.91e-158.09e-010.0875
51157ZNF580P2T-EHumanEsophagusESCC5.29e-548.11e-010.1177
51157ZNF580P4T-EHumanEsophagusESCC2.08e-216.92e-010.1323
51157ZNF580P5T-EHumanEsophagusESCC1.34e-183.52e-010.1327
51157ZNF580P8T-EHumanEsophagusESCC9.72e-981.70e+000.0889
51157ZNF580P9T-EHumanEsophagusESCC3.00e-124.53e-010.1131
51157ZNF580P10T-EHumanEsophagusESCC3.51e-881.24e+000.116
51157ZNF580P11T-EHumanEsophagusESCC7.67e-169.95e-010.1426
51157ZNF580P12T-EHumanEsophagusESCC6.17e-561.03e+000.1122
51157ZNF580P15T-EHumanEsophagusESCC5.93e-501.28e+000.1149
51157ZNF580P16T-EHumanEsophagusESCC7.11e-436.62e-010.1153
51157ZNF580P17T-EHumanEsophagusESCC1.23e-137.45e-010.1278
51157ZNF580P19T-EHumanEsophagusESCC9.24e-099.50e-010.1662
51157ZNF580P20T-EHumanEsophagusESCC5.77e-225.05e-010.1124
51157ZNF580P21T-EHumanEsophagusESCC3.36e-427.39e-010.1617
51157ZNF580P22T-EHumanEsophagusESCC1.27e-831.34e+000.1236
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006979111EsophagusESCCresponse to oxidative stress303/8552446/187237.15e-221.30e-19303
GO:0062197111EsophagusESCCcellular response to chemical stress234/8552337/187235.37e-195.97e-17234
GO:0034599111EsophagusESCCcellular response to oxidative stress197/8552288/187233.76e-152.15e-13197
GO:0000302111EsophagusESCCresponse to reactive oxygen species150/8552222/187233.06e-111.02e-09150
GO:0042542111EsophagusESCCresponse to hydrogen peroxide102/8552146/187232.64e-095.81e-08102
GO:003461420EsophagusESCCcellular response to reactive oxygen species103/8552155/187231.34e-072.17e-06103
GO:00703018EsophagusESCCcellular response to hydrogen peroxide68/855298/187231.70e-062.03e-0568
GO:005067318EsophagusESCCepithelial cell proliferation238/8552437/187231.19e-048.20e-04238
GO:005067817EsophagusESCCregulation of epithelial cell proliferation206/8552381/187235.51e-043.02e-03206
GO:000166720EsophagusESCCameboidal-type cell migration250/8552475/187231.22e-035.97e-03250
GO:000181916EsophagusESCCpositive regulation of cytokine production244/8552467/187232.29e-031.01e-02244
GO:001063120EsophagusESCCepithelial cell migration187/8552357/187236.05e-032.23e-02187
GO:009013220EsophagusESCCepithelium migration188/8552360/187236.96e-032.54e-02188
GO:000268515EsophagusESCCregulation of leukocyte migration114/8552210/187237.26e-032.63e-02114
GO:009013020EsophagusESCCtissue migration190/8552365/187237.91e-032.82e-02190
GO:000697912LiverCirrhoticresponse to oxidative stress196/4634446/187232.80e-195.86e-17196
GO:006219712LiverCirrhoticcellular response to chemical stress147/4634337/187231.84e-141.72e-12147
GO:003459912LiverCirrhoticcellular response to oxidative stress127/4634288/187234.29e-133.32e-11127
GO:000030212LiverCirrhoticresponse to reactive oxygen species100/4634222/187232.92e-111.73e-09100
GO:004254212LiverCirrhoticresponse to hydrogen peroxide71/4634146/187233.40e-101.63e-0871
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZNF580CAFCervixADJSLC25A11,SERTM1,FOXO6, etc.1.77e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF580MVALiverHealthyHES4,MCAM,COL18A1, etc.5.80e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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