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Gene: ZNF574 |
Gene summary for ZNF574 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF574 | Gene ID | 64763 |
| Gene name | zinc finger protein 574 | |
| Gene Alias | FP972 | |
| Cytomap | 19q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0C4DFM2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64763 | ZNF574 | LZE4T | Human | Esophagus | ESCC | 5.53e-04 | 1.76e-01 | 0.0811 |
| 64763 | ZNF574 | LZE7T | Human | Esophagus | ESCC | 2.88e-02 | 1.64e-01 | 0.0667 |
| 64763 | ZNF574 | LZE8T | Human | Esophagus | ESCC | 4.06e-05 | 1.26e-01 | 0.067 |
| 64763 | ZNF574 | LZE24T | Human | Esophagus | ESCC | 3.77e-11 | 3.53e-01 | 0.0596 |
| 64763 | ZNF574 | LZE21T | Human | Esophagus | ESCC | 2.21e-03 | 2.36e-01 | 0.0655 |
| 64763 | ZNF574 | P1T-E | Human | Esophagus | ESCC | 1.12e-06 | 1.92e-01 | 0.0875 |
| 64763 | ZNF574 | P2T-E | Human | Esophagus | ESCC | 1.01e-19 | 3.43e-01 | 0.1177 |
| 64763 | ZNF574 | P4T-E | Human | Esophagus | ESCC | 2.09e-09 | 1.62e-01 | 0.1323 |
| 64763 | ZNF574 | P5T-E | Human | Esophagus | ESCC | 2.92e-17 | 1.73e-01 | 0.1327 |
| 64763 | ZNF574 | P8T-E | Human | Esophagus | ESCC | 3.43e-20 | 3.10e-01 | 0.0889 |
| 64763 | ZNF574 | P10T-E | Human | Esophagus | ESCC | 5.76e-15 | 2.03e-01 | 0.116 |
| 64763 | ZNF574 | P11T-E | Human | Esophagus | ESCC | 1.20e-16 | 7.12e-01 | 0.1426 |
| 64763 | ZNF574 | P12T-E | Human | Esophagus | ESCC | 1.61e-20 | 3.82e-01 | 0.1122 |
| 64763 | ZNF574 | P15T-E | Human | Esophagus | ESCC | 6.84e-20 | 4.18e-01 | 0.1149 |
| 64763 | ZNF574 | P16T-E | Human | Esophagus | ESCC | 1.96e-15 | 2.51e-01 | 0.1153 |
| 64763 | ZNF574 | P20T-E | Human | Esophagus | ESCC | 3.43e-19 | 4.37e-01 | 0.1124 |
| 64763 | ZNF574 | P21T-E | Human | Esophagus | ESCC | 6.65e-10 | 2.56e-02 | 0.1617 |
| 64763 | ZNF574 | P22T-E | Human | Esophagus | ESCC | 3.69e-14 | 1.91e-01 | 0.1236 |
| 64763 | ZNF574 | P23T-E | Human | Esophagus | ESCC | 2.91e-16 | 4.75e-01 | 0.108 |
| 64763 | ZNF574 | P24T-E | Human | Esophagus | ESCC | 4.33e-14 | 1.54e-01 | 0.1287 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF574 | NUER | Prostate | Healthy | PTTG1,HNRNPUL1,COP1, etc. | 8.02e-03 |  |
| ZNF574 | CD8TEREX | Stomach | CAG | CHMP7,AC083798.2,AC080162.1, etc. | 1.19e-02 |  |
| ZNF574 | M2MAC | Stomach | CAG with IM | CHMP7,AC083798.2,AC080162.1, etc. | 1.06e-02 |  |
| ZNF574 | TFH | Stomach | CSG | CHMP7,AC083798.2,AC080162.1, etc. | 6.97e-03 |  |
| ZNF574 | TH17 | Stomach | Healthy | CHMP7,AC083798.2,AC080162.1, etc. | 7.99e-03 |  |
| ZNF574 | MAIT | Stomach | SIM | CHMP7,AC083798.2,AC080162.1, etc. | 2.61e-02 |  |
| ZNF574 | CD8TEREX | Stomach | WIM | CHMP7,AC083798.2,AC080162.1, etc. | 5.60e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF574 | SNV | Missense_Mutation | c.2680N>A | p.Ala894Thr | p.A894T | protein_coding | tolerated(0.42) | benign(0.015) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ZNF574 | SNV | Missense_Mutation | rs766298586 | c.2494N>A | p.Glu832Lys | p.E832K | protein_coding | tolerated(0.24) | possibly_damaging(0.51) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZNF574 | SNV | Missense_Mutation | novel | c.2756N>C | p.Lys919Thr | p.K919T | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZNF574 | SNV | Missense_Mutation | c.2128C>T | p.Arg710Trp | p.R710W | protein_coding | deleterious(0) | benign(0.05) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
| ZNF574 | SNV | Missense_Mutation | novel | c.212T>A | p.Leu71His | p.L71H | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZNF574 | SNV | Missense_Mutation | novel | c.928N>A | p.Ser310Thr | p.S310T | protein_coding | tolerated(0.66) | benign(0.12) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF574 | SNV | Missense_Mutation | rs749203009 | c.2167N>T | p.Arg723Cys | p.R723C | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
| ZNF574 | SNV | Missense_Mutation | rs376193704 | c.797N>A | p.Arg266Gln | p.R266Q | protein_coding | tolerated(0.62) | benign(0.007) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
| ZNF574 | SNV | Missense_Mutation | c.305N>A | p.Ile102Asn | p.I102N | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| ZNF574 | SNV | Missense_Mutation | c.1814G>A | p.Arg605His | p.R605H | protein_coding | deleterious(0.04) | possibly_damaging(0.897) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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