TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF565 | MSC.SEC | Liver | Cirrhotic | NUAK1,CLPTM1L,NRG3, etc. | 2.62e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_Cirrhotic/regulons_activity_in_dotplot.png) |
ZNF565 | MDSC | Prostate | BPH | GPATCH11,ZNF146,EED, etc. | 1.48e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_BPH/regulons_activity_in_dotplot.png) |
ZNF565 | BN | Prostate | Healthy | GPATCH11,ZNF146,EED, etc. | 3.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF565 | CD8TRM | Prostate | Healthy | GPATCH11,ZNF146,EED, etc. | 3.86e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF565 | CD8TCM | Prostate | Healthy | GPATCH11,ZNF146,EED, etc. | 5.55e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF565 | SNV | Missense_Mutation | rs775971742 | c.826N>A | p.Glu276Lys | p.E276K | Q8N9K5 | protein_coding | tolerated(0.05) | possibly_damaging(0.548) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF565 | SNV | Missense_Mutation | | c.1169C>A | p.Pro390His | p.P390H | Q8N9K5 | protein_coding | deleterious(0) | possibly_damaging(0.748) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF565 | SNV | Missense_Mutation | novel | c.506N>A | p.Cys169Tyr | p.C169Y | Q8N9K5 | protein_coding | tolerated(0.06) | probably_damaging(0.956) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
ZNF565 | SNV | Missense_Mutation | rs748261589 | c.1372N>T | p.Arg458Cys | p.R458C | Q8N9K5 | protein_coding | tolerated(0.2) | benign(0.014) | TCGA-AR-A1AX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ZNF565 | SNV | Missense_Mutation | novel | c.1016A>G | p.Glu339Gly | p.E339G | Q8N9K5 | protein_coding | deleterious(0) | benign(0.146) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF565 | SNV | Missense_Mutation | | c.1474N>A | p.Glu492Lys | p.E492K | Q8N9K5 | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ZNF565 | SNV | Missense_Mutation | rs139967939 | c.131N>T | p.Ser44Leu | p.S44L | Q8N9K5 | protein_coding | deleterious(0.03) | benign(0.092) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZNF565 | SNV | Missense_Mutation | novel | c.1057C>T | p.His353Tyr | p.H353Y | Q8N9K5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-LL-A5YN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZNF565 | insertion | Frame_Shift_Ins | novel | c.606_607insCT | p.Ala203LeufsTer65 | p.A203Lfs*65 | Q8N9K5 | protein_coding | | | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ZNF565 | insertion | In_Frame_Ins | novel | c.605_606insAGCCTTTAGACAGCACTCACA | p.Phe204_Ser205insArgGlnHisSerGlnAlaPhe | p.F204_S205insRQHSQAF | Q8N9K5 | protein_coding | | | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |