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Gene: ZNF563 |
Gene summary for ZNF563 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF563 | Gene ID | 147837 |
| Gene name | zinc finger protein 563 | |
| Gene Alias | ZNF563 | |
| Cytomap | 19p13.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TA94 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 147837 | ZNF563 | HCC1_Meng | Human | Liver | HCC | 1.87e-23 | 4.60e-02 | 0.0246 |
| 147837 | ZNF563 | HCC2 | Human | Liver | HCC | 6.42e-05 | 5.50e-01 | 0.5341 |
| 147837 | ZNF563 | HCC5 | Human | Liver | HCC | 4.42e-08 | 1.75e+00 | 0.4932 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF563 | MSC | Esophagus | Healthy | RNU12,RP11-162G10.5,ZBTB25, etc. | 7.41e-03 |  |
| ZNF563 | PERI | Stomach | CSG | TMEM128,BRF2,PRX, etc. | 5.03e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF563 | SNV | Missense_Mutation | c.157N>A | p.Glu53Lys | p.E53K | Q8TA94 | protein_coding | tolerated(0.1) | benign(0.37) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ZNF563 | SNV | Missense_Mutation | c.78N>T | p.Lys26Asn | p.K26N | Q8TA94 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF563 | SNV | Missense_Mutation | rs764764104 | c.1058N>A | p.Arg353Gln | p.R353Q | Q8TA94 | protein_coding | tolerated(0.83) | benign(0.007) | TCGA-C5-A1ML-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
| ZNF563 | SNV | Missense_Mutation | rs762149350 | c.1070N>A | p.Arg357Gln | p.R357Q | Q8TA94 | protein_coding | deleterious(0) | possibly_damaging(0.691) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
| ZNF563 | SNV | Missense_Mutation | rs760842286 | c.1310G>A | p.Arg437Gln | p.R437Q | Q8TA94 | protein_coding | tolerated(0.48) | benign(0.017) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| ZNF563 | SNV | Missense_Mutation | c.78G>T | p.Lys26Asn | p.K26N | Q8TA94 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
| ZNF563 | SNV | Missense_Mutation | c.851N>C | p.Lys284Thr | p.K284T | Q8TA94 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
| ZNF563 | SNV | Missense_Mutation | rs533956905 | c.263N>A | p.Arg88Gln | p.R88Q | Q8TA94 | protein_coding | tolerated(0.06) | benign(0) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
| ZNF563 | SNV | Missense_Mutation | c.1286N>T | p.Ala429Val | p.A429V | Q8TA94 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF563 | SNV | Missense_Mutation | novel | c.85N>G | p.Tyr29Asp | p.Y29D | Q8TA94 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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