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Gene: ZNF551 |
Gene summary for ZNF551 |
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Gene information | Species | Human | Gene symbol | ZNF551 | Gene ID | 90233 |
Gene name | zinc finger protein 551 | |
Gene Alias | ZNF551 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7Z340 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90233 | ZNF551 | RNA-P17T-P17T-2 | Human | Lung | IAC | 4.00e-02 | 5.60e-01 | 0.3371 |
90233 | ZNF551 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.05e-04 | 5.40e-01 | 0.343 |
90233 | ZNF551 | RNA-P17T-P17T-6 | Human | Lung | IAC | 3.47e-04 | 5.38e-01 | 0.3385 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF551 | CD8TEXP | Oral cavity | EOLP | RHOBTB2,ABRAXAS1,ZNF813, etc. | 1.78e-01 | ![]() |
ZNF551 | TH17 | Oral cavity | LP | RHOBTB2,ABRAXAS1,ZNF813, etc. | 2.87e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF551 | SNV | Missense_Mutation | c.2002N>C | p.Glu668Gln | p.E668Q | Q7Z340 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF551 | SNV | Missense_Mutation | novel | c.344A>C | p.Asp115Ala | p.D115A | Q7Z340 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
ZNF551 | SNV | Missense_Mutation | c.1889N>G | p.Leu630Arg | p.L630R | Q7Z340 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
ZNF551 | SNV | Missense_Mutation | c.212G>T | p.Cys71Phe | p.C71F | Q7Z340 | protein_coding | tolerated(0.17) | benign(0.129) | TCGA-D8-A142-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamid | SD | |
ZNF551 | SNV | Missense_Mutation | rs560670635 | c.1627N>T | p.Arg543Cys | p.R543C | Q7Z340 | protein_coding | tolerated(0.19) | possibly_damaging(0.674) | TCGA-E9-A1RH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD |
ZNF551 | insertion | Frame_Shift_Ins | novel | c.1083_1084insAGTT | p.Pro362SerfsTer4 | p.P362Sfs*4 | Q7Z340 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
ZNF551 | insertion | In_Frame_Ins | novel | c.1085_1086insATGCACTCAGTTCTTGTGTCTCACACATTTTTGTGATACATC | p.Pro362_Tyr363insCysThrGlnPheLeuCysLeuThrHisPheCysAspThrSer | p.P362_Y363insCTQFLCLTHFCDTS | Q7Z340 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
ZNF551 | insertion | In_Frame_Ins | novel | c.783_784insATACAATAC | p.Thr261_Cys262insIleGlnTyr | p.T261_C262insIQY | Q7Z340 | protein_coding | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ZNF551 | insertion | Frame_Shift_Ins | novel | c.785_786insTGCTGAATTGTTGTTTCATCTGTCACTTC | p.Lys263AlafsTer42 | p.K263Afs*42 | Q7Z340 | protein_coding | TCGA-A2-A0D4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ZNF551 | insertion | Frame_Shift_Ins | novel | c.822_823insTTTGACCCCAGAGTTACCTCTGTCTCAGGAGTCTTGCTGTCAGCCTA | p.Gly275PhefsTer16 | p.G275Ffs*16 | Q7Z340 | protein_coding | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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