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Gene: ZNF544 |
Gene summary for ZNF544 |
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Gene information | Species | Human | Gene symbol | ZNF544 | Gene ID | 27300 |
Gene name | zinc finger protein 544 | |
Gene Alias | ZNF544 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6NX49 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27300 | ZNF544 | LZE4T | Human | Esophagus | ESCC | 1.44e-08 | 1.38e-01 | 0.0811 |
27300 | ZNF544 | LZE7T | Human | Esophagus | ESCC | 1.60e-10 | 5.85e-01 | 0.0667 |
27300 | ZNF544 | P2T-E | Human | Esophagus | ESCC | 1.98e-12 | 2.93e-01 | 0.1177 |
27300 | ZNF544 | P4T-E | Human | Esophagus | ESCC | 8.92e-12 | 3.17e-01 | 0.1323 |
27300 | ZNF544 | P5T-E | Human | Esophagus | ESCC | 5.03e-11 | 1.57e-01 | 0.1327 |
27300 | ZNF544 | P8T-E | Human | Esophagus | ESCC | 1.67e-22 | 5.01e-01 | 0.0889 |
27300 | ZNF544 | P9T-E | Human | Esophagus | ESCC | 6.05e-04 | 6.68e-02 | 0.1131 |
27300 | ZNF544 | P10T-E | Human | Esophagus | ESCC | 5.37e-40 | 5.61e-01 | 0.116 |
27300 | ZNF544 | P11T-E | Human | Esophagus | ESCC | 4.71e-10 | 5.28e-01 | 0.1426 |
27300 | ZNF544 | P12T-E | Human | Esophagus | ESCC | 1.82e-15 | 2.68e-01 | 0.1122 |
27300 | ZNF544 | P15T-E | Human | Esophagus | ESCC | 3.19e-08 | 1.58e-01 | 0.1149 |
27300 | ZNF544 | P16T-E | Human | Esophagus | ESCC | 2.78e-12 | 2.23e-01 | 0.1153 |
27300 | ZNF544 | P17T-E | Human | Esophagus | ESCC | 3.40e-09 | 2.04e-01 | 0.1278 |
27300 | ZNF544 | P20T-E | Human | Esophagus | ESCC | 5.45e-04 | 8.01e-02 | 0.1124 |
27300 | ZNF544 | P21T-E | Human | Esophagus | ESCC | 1.05e-11 | 1.68e-01 | 0.1617 |
27300 | ZNF544 | P22T-E | Human | Esophagus | ESCC | 8.52e-17 | 2.57e-01 | 0.1236 |
27300 | ZNF544 | P23T-E | Human | Esophagus | ESCC | 2.29e-07 | 1.29e-01 | 0.108 |
27300 | ZNF544 | P24T-E | Human | Esophagus | ESCC | 2.78e-08 | 1.95e-01 | 0.1287 |
27300 | ZNF544 | P26T-E | Human | Esophagus | ESCC | 4.44e-15 | 2.75e-01 | 0.1276 |
27300 | ZNF544 | P27T-E | Human | Esophagus | ESCC | 1.79e-13 | 3.06e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF544 | SNV | Missense_Mutation | c.1318G>C | p.Glu440Gln | p.E440Q | Q6NX49 | protein_coding | tolerated(0.12) | benign(0.091) | TCGA-A1-A0SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF544 | SNV | Missense_Mutation | c.1447A>G | p.Lys483Glu | p.K483E | Q6NX49 | protein_coding | tolerated(0.19) | benign(0.013) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |
ZNF544 | SNV | Missense_Mutation | novel | c.922T>A | p.Ser308Thr | p.S308T | Q6NX49 | protein_coding | tolerated(0.55) | benign(0.012) | TCGA-A8-A07I-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
ZNF544 | SNV | Missense_Mutation | novel | c.922N>A | p.Ser308Thr | p.S308T | Q6NX49 | protein_coding | tolerated(0.55) | benign(0.012) | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD |
ZNF544 | SNV | Missense_Mutation | c.2035N>T | p.His679Tyr | p.H679Y | Q6NX49 | protein_coding | tolerated(0.07) | benign(0.067) | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |
ZNF544 | SNV | Missense_Mutation | c.901N>A | p.Asp301Asn | p.D301N | Q6NX49 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF544 | SNV | Missense_Mutation | novel | c.426C>G | p.Phe142Leu | p.F142L | Q6NX49 | protein_coding | tolerated(0.8) | benign(0.04) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ZNF544 | SNV | Missense_Mutation | novel | c.923C>A | p.Ser308Tyr | p.S308Y | Q6NX49 | protein_coding | tolerated(1) | benign(0.144) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ZNF544 | SNV | Missense_Mutation | c.1358N>C | p.Val453Ala | p.V453A | Q6NX49 | protein_coding | tolerated(1) | benign(0.028) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF544 | SNV | Missense_Mutation | c.189C>G | p.Ile63Met | p.I63M | Q6NX49 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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