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Gene: ZNF527 |
Gene summary for ZNF527 |
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Gene information | Species | Human | Gene symbol | ZNF527 | Gene ID | 84503 |
Gene name | zinc finger protein 527 | |
Gene Alias | ZNF527 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NB42 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84503 | ZNF527 | HCC1 | Human | Liver | HCC | 5.56e-11 | 1.24e+00 | 0.5336 |
84503 | ZNF527 | HCC2 | Human | Liver | HCC | 2.41e-23 | 2.42e+00 | 0.5341 |
84503 | ZNF527 | HCC5 | Human | Liver | HCC | 5.98e-16 | 1.38e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF527 | SNV | Missense_Mutation | novel | c.559A>G | p.Ile187Val | p.I187V | Q8NB42 | protein_coding | tolerated(0.65) | benign(0) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ZNF527 | SNV | Missense_Mutation | c.1579N>A | p.Glu527Lys | p.E527K | Q8NB42 | protein_coding | tolerated(0.24) | benign(0.005) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF527 | SNV | Missense_Mutation | c.1558N>T | p.His520Tyr | p.H520Y | Q8NB42 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF527 | SNV | Missense_Mutation | novel | c.881N>T | p.Arg294Ile | p.R294I | Q8NB42 | protein_coding | deleterious(0.01) | benign(0.019) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF527 | SNV | Missense_Mutation | c.802N>T | p.His268Tyr | p.H268Y | Q8NB42 | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF527 | SNV | Missense_Mutation | novel | c.1322C>T | p.Pro441Leu | p.P441L | Q8NB42 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZNF527 | insertion | Nonsense_Mutation | novel | c.1466_1467insCCATGTTGGAAAATAACTGTAGTCTTCTCCCATCAGGCTTCTTT | p.Arg490HisfsTer5 | p.R490Hfs*5 | Q8NB42 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
ZNF527 | SNV | Missense_Mutation | c.648N>T | p.Lys216Asn | p.K216N | Q8NB42 | protein_coding | deleterious(0.03) | benign(0.112) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF527 | SNV | Missense_Mutation | rs369844658 | c.1276C>T | p.Arg426Cys | p.R426C | Q8NB42 | protein_coding | tolerated(0.07) | benign(0.42) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF527 | SNV | Missense_Mutation | c.1810N>T | p.His604Tyr | p.H604Y | Q8NB42 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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