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Gene: ZNF525 |
Gene summary for ZNF525 |
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Gene information | Species | Human | Gene symbol | ZNF525 | Gene ID | 170958 |
Gene name | zinc finger protein 525 | |
Gene Alias | ZNF525 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | J3KR51 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
170958 | ZNF525 | HCC1_Meng | Human | Liver | HCC | 3.60e-07 | 1.33e-02 | 0.0246 |
170958 | ZNF525 | HCC1 | Human | Liver | HCC | 1.78e-04 | 1.44e+00 | 0.5336 |
170958 | ZNF525 | HCC2 | Human | Liver | HCC | 2.07e-12 | 2.40e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF525 | SNV | Missense_Mutation | novel | c.1106N>G | p.Asn369Ser | p.N369S | protein_coding | tolerated(0.95) | benign(0) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF525 | SNV | Missense_Mutation | novel | c.1292N>T | p.Arg431Ile | p.R431I | protein_coding | tolerated(0.13) | benign(0.072) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF525 | SNV | Missense_Mutation | c.1388N>T | p.Gly463Val | p.G463V | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-C8-A1HE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF525 | SNV | Missense_Mutation | c.1304G>C | p.Gly435Ala | p.G435A | protein_coding | deleterious(0.01) | benign(0.18) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | ||
ZNF525 | SNV | Missense_Mutation | c.1159N>A | p.Asp387Asn | p.D387N | protein_coding | deleterious(0) | benign(0.189) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF525 | SNV | Missense_Mutation | c.1116T>A | p.Ser372Arg | p.S372R | protein_coding | tolerated(0.7) | benign(0.001) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ZNF525 | SNV | Missense_Mutation | novel | c.277G>T | p.Asp93Tyr | p.D93Y | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF525 | SNV | Missense_Mutation | rs183665728 | c.784N>T | p.Arg262Cys | p.R262C | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
ZNF525 | SNV | Missense_Mutation | novel | c.317G>T | p.Arg106Ile | p.R106I | protein_coding | tolerated(0.06) | possibly_damaging(0.549) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF525 | SNV | Missense_Mutation | c.1219N>A | p.Gly407Arg | p.G407R | protein_coding | deleterious(0.02) | possibly_damaging(0.625) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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