Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZNF524

Gene summary for ZNF524

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZNF524

Gene ID

147807

Gene namezinc finger protein 524
Gene AliasZNF524
Cytomap19q13.42
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q96C55


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
147807ZNF524LZE4THumanEsophagusESCC5.46e-112.18e-010.0811
147807ZNF524LZE7THumanEsophagusESCC2.22e-042.54e-010.0667
147807ZNF524LZE22D1HumanEsophagusHGIN1.99e-042.11e-010.0595
147807ZNF524LZE24THumanEsophagusESCC5.64e-134.32e-010.0596
147807ZNF524P1T-EHumanEsophagusESCC2.74e-074.45e-010.0875
147807ZNF524P2T-EHumanEsophagusESCC1.35e-041.62e-010.1177
147807ZNF524P4T-EHumanEsophagusESCC1.90e-153.12e-010.1323
147807ZNF524P5T-EHumanEsophagusESCC4.17e-045.94e-020.1327
147807ZNF524P8T-EHumanEsophagusESCC1.70e-357.04e-010.0889
147807ZNF524P9T-EHumanEsophagusESCC1.96e-133.10e-010.1131
147807ZNF524P10T-EHumanEsophagusESCC1.68e-092.08e-010.116
147807ZNF524P11T-EHumanEsophagusESCC4.43e-074.22e-010.1426
147807ZNF524P12T-EHumanEsophagusESCC1.35e-142.01e-010.1122
147807ZNF524P15T-EHumanEsophagusESCC2.03e-143.20e-010.1149
147807ZNF524P16T-EHumanEsophagusESCC2.01e-033.59e-020.1153
147807ZNF524P17T-EHumanEsophagusESCC6.22e-124.67e-010.1278
147807ZNF524P19T-EHumanEsophagusESCC7.14e-064.65e-010.1662
147807ZNF524P20T-EHumanEsophagusESCC3.06e-102.88e-010.1124
147807ZNF524P21T-EHumanEsophagusESCC1.28e-203.67e-010.1617
147807ZNF524P22T-EHumanEsophagusESCC1.84e-184.11e-010.1236
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZNF524INMONBreastADJDRAIC,CLPB,SERPINE2, etc.7.51e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524CD8TEFFBreastHealthyDRAIC,CLPB,SERPINE2, etc.4.21e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524NKBreastPrecancerDRAIC,CLPB,SERPINE2, etc.4.89e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524INMONPancreasPDACSPARCL1,SPRY1,IGFBP4, etc.1.11e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524CD8TEXINTPancreasPDACSPARCL1,SPRY1,IGFBP4, etc.9.06e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524BMEMPancreasPDACSPARCL1,SPRY1,IGFBP4, etc.6.84e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524M1MACPancreasPDACSPARCL1,SPRY1,IGFBP4, etc.7.75e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524TREGProstateTumorCOL6A2,GFER,NOXA1, etc.1.38e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524CD8TEXINTSkinADJSELENOK,BNIP3,NEXN, etc.1.19e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF524CD8TEXINTSkincSCCSELENOK,BNIP3,NEXN, etc.1.63e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZNF524SNVMissense_Mutationnovelc.262G>Cp.Asp88Hisp.D88HQ96C55protein_codingtolerated(0.1)probably_damaging(0.999)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ZNF524SNVMissense_Mutationnovelc.394N>Ap.His132Asnp.H132NQ96C55protein_codingdeleterious(0)probably_damaging(0.997)TCGA-DM-A1HB-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
ZNF524SNVMissense_Mutationrs141376459c.23N>Tp.Pro8Leup.P8LQ96C55protein_codingdeleterious_low_confidence(0.04)possibly_damaging(0.456)TCGA-F4-6807-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyxelodaCR
ZNF524deletionFrame_Shift_Delc.214delGp.Val72Terp.V72*Q96C55protein_codingTCGA-5M-AAT6-01Colorectumcolon adenocarcinomaFemale<65III/IVUnknownUnknownPD
ZNF524deletionFrame_Shift_Delc.210delNp.Val72Terp.V72*Q96C55protein_codingTCGA-A6-6653-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
ZNF524insertionFrame_Shift_Insrs750719825c.167_168insCp.Lys59GlnfsTer31p.K59Qfs*31Q96C55protein_codingTCGA-AA-3492-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
ZNF524SNVMissense_Mutationnovelc.48G>Tp.Glu16Aspp.E16DQ96C55protein_codingdeleterious_low_confidence(0.03)possibly_damaging(0.672)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
ZNF524SNVMissense_Mutationnovelc.392N>Ap.Arg131Hisp.R131HQ96C55protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AJ-A3OL-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinPD
ZNF524SNVMissense_Mutationnovelc.302N>Tp.Ala101Valp.A101VQ96C55protein_codingtolerated(0.41)benign(0.006)TCGA-AX-A3FS-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF524SNVMissense_Mutationc.131N>Ap.Arg44Glnp.R44QQ96C55protein_codingtolerated_low_confidence(0.47)benign(0)TCGA-D1-A103-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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