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Gene: ZNF521 |
Gene summary for ZNF521 |
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Gene information | Species | Human | Gene symbol | ZNF521 | Gene ID | 25925 |
Gene name | zinc finger protein 521 | |
Gene Alias | EHZF | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | J3KTI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25925 | ZNF521 | ATC12 | Human | Thyroid | ATC | 2.71e-08 | 1.55e-01 | 0.34 |
25925 | ZNF521 | ATC13 | Human | Thyroid | ATC | 1.72e-28 | 5.06e-01 | 0.34 |
25925 | ZNF521 | ATC2 | Human | Thyroid | ATC | 5.35e-04 | 3.20e-01 | 0.34 |
25925 | ZNF521 | ATC4 | Human | Thyroid | ATC | 2.47e-08 | 1.87e-01 | 0.34 |
25925 | ZNF521 | ATC5 | Human | Thyroid | ATC | 1.81e-27 | 5.56e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF521 | SNV | Missense_Mutation | c.3548G>A | p.Arg1183Lys | p.R1183K | Q96K83 | protein_coding | tolerated_low_confidence(0.53) | benign(0.019) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF521 | SNV | Missense_Mutation | novel | c.3364N>C | p.Glu1122Gln | p.E1122Q | Q96K83 | protein_coding | tolerated(0.55) | benign(0.094) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
ZNF521 | SNV | Missense_Mutation | rs752301261 | c.597N>A | p.Asn199Lys | p.N199K | Q96K83 | protein_coding | tolerated(0.1) | possibly_damaging(0.626) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
ZNF521 | SNV | Missense_Mutation | rs201246445 | c.2635N>A | p.Val879Ile | p.V879I | Q96K83 | protein_coding | tolerated(0.64) | benign(0.005) | TCGA-AR-A0TW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD |
ZNF521 | SNV | Missense_Mutation | novel | c.1013N>A | p.Cys338Tyr | p.C338Y | Q96K83 | protein_coding | tolerated(0.09) | benign(0.396) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF521 | SNV | Missense_Mutation | novel | c.3328C>A | p.Pro1110Thr | p.P1110T | Q96K83 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZNF521 | insertion | Nonsense_Mutation | novel | c.3057_3058insATTTATTAAGCACCACATGCCCATTATTCTG | p.Phe1020IlefsTer3 | p.F1020Ifs*3 | Q96K83 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ZNF521 | insertion | Nonsense_Mutation | novel | c.1174_1175insCGGAGAGCGGTTTCCCTCCCTTTTAACTCTT | p.Asp392AlafsTer9 | p.D392Afs*9 | Q96K83 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF521 | insertion | Nonsense_Mutation | novel | c.1769_1770insTGTTAGCCAAGTTAAATTTCTATAAGTTCTCATTTTGA | p.Leu590PhefsTer9 | p.L590Ffs*9 | Q96K83 | protein_coding | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
ZNF521 | insertion | Frame_Shift_Ins | novel | c.2238_2239insCCTTTGG | p.Asn747ProfsTer9 | p.N747Pfs*9 | Q96K83 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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