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Gene: ZNF514 |
Gene summary for ZNF514 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF514 | Gene ID | 84874 |
Gene name | zinc finger protein 514 | |
Gene Alias | ZNF514 | |
Cytomap | 2q11.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96K75 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84874 | ZNF514 | HCC1_Meng | Human | Liver | HCC | 3.12e-25 | 3.27e-02 | 0.0246 |
84874 | ZNF514 | HCC2_Meng | Human | Liver | HCC | 9.47e-06 | 5.52e-02 | 0.0107 |
84874 | ZNF514 | HCC1 | Human | Liver | HCC | 2.85e-06 | 2.32e+00 | 0.5336 |
84874 | ZNF514 | HCC2 | Human | Liver | HCC | 6.06e-11 | 3.16e+00 | 0.5341 |
84874 | ZNF514 | HCC5 | Human | Liver | HCC | 3.63e-04 | 1.38e+00 | 0.4932 |
84874 | ZNF514 | S014 | Human | Liver | HCC | 1.26e-03 | 3.04e-01 | 0.2254 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF514 | SNV | Missense_Mutation | c.1091N>T | p.Arg364Ile | p.R364I | Q96K75 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF514 | SNV | Missense_Mutation | novel | c.243N>T | p.Lys81Asn | p.K81N | Q96K75 | protein_coding | tolerated(0.09) | benign(0.137) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF514 | SNV | Missense_Mutation | novel | c.395N>A | p.Arg132Lys | p.R132K | Q96K75 | protein_coding | tolerated(0.23) | benign(0) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF514 | insertion | Frame_Shift_Ins | novel | c.250_251insGCTTGCAGTCAGCCGAGATCACGCCACTGCACTCCAGC | p.Met84SerfsTer27 | p.M84Sfs*27 | Q96K75 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ZNF514 | deletion | Frame_Shift_Del | novel | c.1delA | p.Met1? | p.M1? | Q96K75 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF514 | SNV | Missense_Mutation | novel | c.760C>T | p.His254Tyr | p.H254Y | Q96K75 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-ZJ-AAXN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF514 | SNV | Missense_Mutation | c.502N>G | p.Asn168Asp | p.N168D | Q96K75 | protein_coding | tolerated(0.07) | benign(0.035) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF514 | SNV | Missense_Mutation | c.439C>A | p.Leu147Ile | p.L147I | Q96K75 | protein_coding | tolerated(0.41) | benign(0.018) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF514 | SNV | Missense_Mutation | c.608C>A | p.Ser203Tyr | p.S203Y | Q96K75 | protein_coding | deleterious(0.04) | benign(0.365) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF514 | SNV | Missense_Mutation | c.685N>A | p.Glu229Lys | p.E229K | Q96K75 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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