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Gene: ZNF500 |
Gene summary for ZNF500 |
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Gene information | Species | Human | Gene symbol | ZNF500 | Gene ID | 26048 |
Gene name | zinc finger protein 500 | |
Gene Alias | ZKSCAN18 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60304 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26048 | ZNF500 | HCC1_Meng | Human | Liver | HCC | 3.14e-08 | -3.48e-02 | 0.0246 |
26048 | ZNF500 | HCC2_Meng | Human | Liver | HCC | 9.79e-03 | 5.68e-03 | 0.0107 |
26048 | ZNF500 | HCC1 | Human | Liver | HCC | 1.22e-05 | 1.14e+00 | 0.5336 |
26048 | ZNF500 | HCC2 | Human | Liver | HCC | 3.32e-16 | 1.57e+00 | 0.5341 |
26048 | ZNF500 | HCC5 | Human | Liver | HCC | 2.58e-07 | 2.14e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF500 | SNV | Missense_Mutation | c.419N>T | p.Ser140Leu | p.S140L | O60304 | protein_coding | tolerated(0.78) | benign(0) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD | |
ZNF500 | SNV | Missense_Mutation | novel | c.253A>T | p.Thr85Ser | p.T85S | O60304 | protein_coding | tolerated(0.16) | benign(0.165) | TCGA-LL-A740-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZNF500 | SNV | Missense_Mutation | rs751428724 | c.344C>T | p.Pro115Leu | p.P115L | O60304 | protein_coding | tolerated(1) | probably_damaging(0.999) | TCGA-OL-A5D7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
ZNF500 | insertion | Frame_Shift_Ins | novel | c.973_974insGGCGGCAC | p.Tyr325TrpfsTer19 | p.Y325Wfs*19 | O60304 | protein_coding | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | ||
ZNF500 | SNV | Missense_Mutation | rs139150092 | c.629C>T | p.Ala210Val | p.A210V | O60304 | protein_coding | tolerated(0.21) | benign(0.075) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF500 | SNV | Missense_Mutation | c.1034G>A | p.Arg345His | p.R345H | O60304 | protein_coding | tolerated(0.07) | benign(0.386) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF500 | SNV | Missense_Mutation | rs374630511 | c.332N>A | p.Arg111His | p.R111H | O60304 | protein_coding | tolerated(0.07) | probably_damaging(0.984) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF500 | SNV | Missense_Mutation | c.1073N>A | p.Cys358Tyr | p.C358Y | O60304 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F4-6854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF500 | SNV | Missense_Mutation | c.982N>G | p.Pro328Ala | p.P328A | O60304 | protein_coding | tolerated(0.17) | benign(0.05) | TCGA-CL-5918-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF500 | SNV | Missense_Mutation | c.985N>A | p.Glu329Lys | p.E329K | O60304 | protein_coding | deleterious(0.01) | benign(0.078) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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