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Gene: ZNF496 |
Gene summary for ZNF496 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF496 | Gene ID | 84838 |
| Gene name | zinc finger protein 496 | |
| Gene Alias | NIZP1 | |
| Cytomap | 1q44 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R5Q5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84838 | ZNF496 | HCC1_Meng | Human | Liver | HCC | 2.06e-25 | 5.30e-02 | 0.0246 |
| 84838 | ZNF496 | HCC1 | Human | Liver | HCC | 8.25e-03 | 2.85e+00 | 0.5336 |
| 84838 | ZNF496 | HCC2 | Human | Liver | HCC | 4.91e-02 | 1.00e+00 | 0.5341 |
| 84838 | ZNF496 | S014 | Human | Liver | HCC | 1.56e-12 | 3.96e-01 | 0.2254 |
| 84838 | ZNF496 | S015 | Human | Liver | HCC | 6.57e-07 | 3.21e-01 | 0.2375 |
| 84838 | ZNF496 | S016 | Human | Liver | HCC | 5.06e-11 | 3.47e-01 | 0.2243 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF496 | BN | Colorectum | CRC | INSIG2,GYG1,TADA1, etc. | 1.67e-02 |  |
| ZNF496 | TH17 | Colorectum | FAP | INSIG2,GYG1,TADA1, etc. | 5.70e-02 |  |
| ZNF496 | CD8TEXINT | Colorectum | MSI-H | INSIG2,GYG1,TADA1, etc. | 3.77e-02 |  |
| ZNF496 | MAIT | Colorectum | MSI-H | INSIG2,GYG1,TADA1, etc. | 3.46e-02 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF496 | SNV | Missense_Mutation | novel | c.8N>T | p.Thr3Ile | p.T3I | Q96IT1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| ZNF496 | SNV | Missense_Mutation | novel | c.694N>A | p.Glu232Lys | p.E232K | Q96IT1 | protein_coding | deleterious(0.01) | benign(0.396) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
| ZNF496 | SNV | Missense_Mutation | c.215N>T | p.Arg72Leu | p.R72L | Q96IT1 | protein_coding | deleterious(0) | possibly_damaging(0.643) | TCGA-AR-A24Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| ZNF496 | SNV | Missense_Mutation | rs754694981 | c.835N>T | p.Arg279Cys | p.R279C | Q96IT1 | protein_coding | tolerated(0.14) | benign(0) | TCGA-BH-A0EI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF496 | SNV | Missense_Mutation | c.1192G>A | p.Glu398Lys | p.E398K | Q96IT1 | protein_coding | tolerated(0.27) | benign(0.272) | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF496 | SNV | Missense_Mutation | c.220N>A | p.Glu74Lys | p.E74K | Q96IT1 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZNF496 | SNV | Missense_Mutation | c.307N>T | p.Arg103Trp | p.R103W | Q96IT1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF496 | SNV | Missense_Mutation | c.406N>T | p.Asp136Tyr | p.D136Y | Q96IT1 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| ZNF496 | SNV | Missense_Mutation | c.254N>G | p.Leu85Arg | p.L85R | Q96IT1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| ZNF496 | SNV | Missense_Mutation | c.1514N>T | p.Ala505Val | p.A505V | Q96IT1 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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