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Gene: ZNF492 |
Gene summary for ZNF492 |
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Gene information | Species | Human | Gene symbol | ZNF492 | Gene ID | 57615 |
Gene name | zinc finger protein 492 | |
Gene Alias | ZNF115 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9P255 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57615 | ZNF492 | HCC1_Meng | Human | Liver | HCC | 2.00e-07 | 1.01e-02 | 0.0246 |
57615 | ZNF492 | HCC1 | Human | Liver | HCC | 1.73e-06 | 1.52e+00 | 0.5336 |
57615 | ZNF492 | HCC2 | Human | Liver | HCC | 8.11e-13 | 1.26e+00 | 0.5341 |
57615 | ZNF492 | HCC5 | Human | Liver | HCC | 2.39e-07 | 1.31e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF492 | SNV | Missense_Mutation | c.1438G>A | p.Glu480Lys | p.E480K | Q9P255 | protein_coding | tolerated(0.16) | benign(0.162) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF492 | SNV | Missense_Mutation | rs551588064 | c.1154N>T | p.Arg385Ile | p.R385I | Q9P255 | protein_coding | tolerated(0.5) | benign(0.005) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF492 | SNV | Missense_Mutation | novel | c.1043N>T | p.Gln348Leu | p.Q348L | Q9P255 | protein_coding | tolerated(0.71) | benign(0.003) | TCGA-C8-A3M8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
ZNF492 | SNV | Missense_Mutation | c.494N>T | p.Gly165Val | p.G165V | Q9P255 | protein_coding | tolerated(0.09) | possibly_damaging(0.713) | TCGA-D8-A140-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin+cyclophosphamid | SD | |
ZNF492 | SNV | Missense_Mutation | novel | c.1411N>T | p.His471Tyr | p.H471Y | Q9P255 | protein_coding | deleterious(0.01) | possibly_damaging(0.633) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ZNF492 | SNV | Missense_Mutation | c.1288N>A | p.Phe430Ile | p.F430I | Q9P255 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF492 | SNV | Missense_Mutation | c.622N>T | p.Arg208Trp | p.R208W | Q9P255 | protein_coding | tolerated(0.55) | benign(0.005) | TCGA-JX-A3PZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF492 | SNV | Missense_Mutation | novel | c.979N>T | p.His327Tyr | p.H327Y | Q9P255 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF492 | SNV | Missense_Mutation | c.593N>C | p.Lys198Thr | p.K198T | Q9P255 | protein_coding | deleterious(0.03) | probably_damaging(0.942) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
ZNF492 | SNV | Missense_Mutation | rs551588064 | c.1154N>T | p.Arg385Ile | p.R385I | Q9P255 | protein_coding | tolerated(0.5) | benign(0.005) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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