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Gene: ZNF483 |
Gene summary for ZNF483 |
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Gene information | Species | Human | Gene symbol | ZNF483 | Gene ID | 158399 |
Gene name | zinc finger protein 483 | |
Gene Alias | ZKSCAN16 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TF39 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158399 | ZNF483 | HCC1 | Human | Liver | HCC | 2.40e-14 | 1.84e+00 | 0.5336 |
158399 | ZNF483 | HCC2 | Human | Liver | HCC | 2.95e-21 | 1.93e+00 | 0.5341 |
158399 | ZNF483 | HCC5 | Human | Liver | HCC | 1.01e-16 | 1.59e+00 | 0.4932 |
158399 | ZNF483 | HTA12-15-2 | Human | Pancreas | PDAC | 4.45e-06 | 4.27e-01 | 0.2315 |
158399 | ZNF483 | HTA12-23-1 | Human | Pancreas | PDAC | 8.00e-12 | 8.15e-01 | 0.3405 |
158399 | ZNF483 | HTA12-25-1 | Human | Pancreas | PDAC | 1.68e-12 | 7.29e-01 | 0.313 |
158399 | ZNF483 | HTA12-26-1 | Human | Pancreas | PDAC | 5.15e-30 | 1.01e+00 | 0.3728 |
158399 | ZNF483 | HTA12-29-1 | Human | Pancreas | PDAC | 5.38e-40 | 7.37e-01 | 0.3722 |
158399 | ZNF483 | HTA12-9-3 | Human | Pancreas | PDAC | 8.76e-04 | 6.05e-01 | 0.2045 |
158399 | ZNF483 | male-WTA | Human | Thyroid | PTC | 3.45e-19 | 3.05e-01 | 0.1037 |
158399 | ZNF483 | PTC01 | Human | Thyroid | PTC | 8.32e-03 | 1.40e-01 | 0.1899 |
158399 | ZNF483 | PTC04 | Human | Thyroid | PTC | 9.63e-11 | 1.90e-01 | 0.1927 |
158399 | ZNF483 | PTC05 | Human | Thyroid | PTC | 1.97e-14 | 5.00e-01 | 0.2065 |
158399 | ZNF483 | PTC06 | Human | Thyroid | PTC | 3.78e-19 | 4.40e-01 | 0.2057 |
158399 | ZNF483 | PTC07 | Human | Thyroid | PTC | 4.08e-21 | 3.55e-01 | 0.2044 |
158399 | ZNF483 | ATC13 | Human | Thyroid | ATC | 1.29e-04 | 9.28e-02 | 0.34 |
158399 | ZNF483 | ATC5 | Human | Thyroid | ATC | 1.80e-05 | 9.94e-02 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF483 | NK | Esophagus | ADJ | BDNF-AS,COL13A1,TGFB3, etc. | 1.26e-01 | ![]() |
ZNF483 | NK | Esophagus | ESCC | BDNF-AS,COL13A1,TGFB3, etc. | 7.43e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF483 | SNV | Missense_Mutation | c.659N>T | p.Ser220Phe | p.S220F | Q8TF39 | protein_coding | tolerated(0.08) | benign(0.344) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF483 | SNV | Missense_Mutation | novel | c.1170N>C | p.Gln390His | p.Q390H | Q8TF39 | protein_coding | tolerated(0.56) | benign(0.275) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF483 | SNV | Missense_Mutation | c.1628N>A | p.Arg543Gln | p.R543Q | Q8TF39 | protein_coding | deleterious(0.01) | probably_damaging(0.958) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF483 | SNV | Missense_Mutation | c.1999N>C | p.Glu667Gln | p.E667Q | Q8TF39 | protein_coding | deleterious(0.01) | benign(0.312) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZNF483 | SNV | Missense_Mutation | novel | c.2060N>C | p.Gly687Ala | p.G687A | Q8TF39 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-BH-A0DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZNF483 | SNV | Missense_Mutation | rs549371082 | c.988N>T | p.Arg330Trp | p.R330W | Q8TF39 | protein_coding | tolerated(0.18) | possibly_damaging(0.543) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF483 | SNV | Missense_Mutation | novel | c.349C>T | p.Pro117Ser | p.P117S | Q8TF39 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZNF483 | SNV | Missense_Mutation | novel | c.1395N>C | p.Lys465Asn | p.K465N | Q8TF39 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF483 | SNV | Missense_Mutation | c.1810N>A | p.Glu604Lys | p.E604K | Q8TF39 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF483 | SNV | Missense_Mutation | c.1288G>A | p.Glu430Lys | p.E430K | Q8TF39 | protein_coding | tolerated(0.33) | benign(0.012) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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