TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF461 | CAF | Cervix | CC | VEGFD,NECAB1,PCF11-AS1, etc. | 4.44e-16 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF461 | MVA | Cervix | CC | VEGFD,NECAB1,PCF11-AS1, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF461 | PERI | Cervix | CC | VEGFD,NECAB1,PCF11-AS1, etc. | 2.72e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF461 | MYOFIB | Esophagus | ESCC | LRRC75B,NISCH,ACSS1, etc. | 2.60e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ESCC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF461 | SNV | Missense_Mutation | | c.868N>G | p.Leu290Val | p.L290V | Q8TAF7 | protein_coding | tolerated(0.62) | benign(0.113) | TCGA-A7-A26H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD |
ZNF461 | SNV | Missense_Mutation | novel | c.1660N>T | p.Leu554Phe | p.L554F | Q8TAF7 | protein_coding | tolerated_low_confidence(0.28) | benign(0) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
ZNF461 | SNV | Missense_Mutation | novel | c.153N>C | p.Lys51Asn | p.K51N | Q8TAF7 | protein_coding | deleterious(0.01) | possibly_damaging(0.766) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ZNF461 | SNV | Missense_Mutation | | c.605G>A | p.Ser202Asn | p.S202N | Q8TAF7 | protein_coding | tolerated(0.43) | benign(0.007) | TCGA-D8-A1XB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF461 | SNV | Missense_Mutation | | c.1511A>C | p.Lys504Thr | p.K504T | Q8TAF7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A1L7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
ZNF461 | SNV | Missense_Mutation | | c.257A>G | p.His86Arg | p.H86R | Q8TAF7 | protein_coding | tolerated(0.66) | benign(0) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZNF461 | SNV | Missense_Mutation | novel | c.896A>G | p.Lys299Arg | p.K299R | Q8TAF7 | protein_coding | tolerated(0.18) | possibly_damaging(0.649) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZNF461 | insertion | Frame_Shift_Ins | novel | c.334_335insGCGGGAAGGCGTTTAATCATAGATTACAA | p.Ser112CysfsTer65 | p.S112Cfs*65 | Q8TAF7 | protein_coding | | | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZNF461 | insertion | In_Frame_Ins | novel | c.1373_1374insCATTGGAATGTGGCCAGATATGCTGGC | p.Arg458delinsSerIleGlyMetTrpProAspMetLeuAla | p.R458delinsSIGMWPDMLA | Q8TAF7 | protein_coding | | | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZNF461 | insertion | Frame_Shift_Ins | novel | c.420_421insAAAGAATGTGGGAAGGCCTTTAGACAGCGATCACAGCTTAC | p.Phe141LysfsTer40 | p.F141Kfs*40 | Q8TAF7 | protein_coding | | | TCGA-AO-A0JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |