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Gene: ZNF454 |
Gene summary for ZNF454 |
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Gene information | Species | Human | Gene symbol | ZNF454 | Gene ID | 285676 |
Gene name | zinc finger protein 454 | |
Gene Alias | ZNF454 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N9F8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285676 | ZNF454 | HCC1_Meng | Human | Liver | HCC | 1.37e-05 | 1.06e-02 | 0.0246 |
285676 | ZNF454 | HCC1 | Human | Liver | HCC | 7.19e-14 | 1.35e+00 | 0.5336 |
285676 | ZNF454 | HCC2 | Human | Liver | HCC | 2.06e-27 | 1.71e+00 | 0.5341 |
285676 | ZNF454 | HCC5 | Human | Liver | HCC | 2.97e-19 | 1.18e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF454 | SNV | Missense_Mutation | novel | c.79N>A | p.Glu27Lys | p.E27K | Q8N9F8 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ZNF454 | SNV | Missense_Mutation | c.802N>A | p.Gly268Arg | p.G268R | Q8N9F8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
ZNF454 | SNV | Missense_Mutation | c.1394A>G | p.Glu465Gly | p.E465G | Q8N9F8 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
ZNF454 | SNV | Missense_Mutation | c.646N>C | p.Tyr216His | p.Y216H | Q8N9F8 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-A8-A08T-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZNF454 | SNV | Missense_Mutation | c.770N>A | p.Ser257Tyr | p.S257Y | Q8N9F8 | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF454 | SNV | Missense_Mutation | novel | c.310N>A | p.Glu104Lys | p.E104K | Q8N9F8 | protein_coding | tolerated(0.69) | benign(0.037) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF454 | SNV | Missense_Mutation | rs370913285 | c.1127N>T | p.Arg376Ile | p.R376I | Q8N9F8 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF454 | SNV | Missense_Mutation | novel | c.1084G>T | p.Gly362Trp | p.G362W | Q8N9F8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-OL-A6VR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF454 | SNV | Missense_Mutation | c.770N>T | p.Ser257Phe | p.S257F | Q8N9F8 | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-C5-A1MJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF454 | SNV | Missense_Mutation | c.405N>G | p.Ile135Met | p.I135M | Q8N9F8 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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