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Gene: ZNF44 |
Gene summary for ZNF44 |
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Gene information | Species | Human | Gene symbol | ZNF44 | Gene ID | 51710 |
Gene name | zinc finger protein 44 | |
Gene Alias | GIOT-2 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P15621 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51710 | ZNF44 | NAFLD1 | Human | Liver | NAFLD | 1.84e-05 | 5.62e-01 | -0.04 |
51710 | ZNF44 | S43 | Human | Liver | Cirrhotic | 6.31e-07 | -1.09e-01 | -0.0187 |
51710 | ZNF44 | HCC1_Meng | Human | Liver | HCC | 1.71e-24 | -3.74e-02 | 0.0246 |
51710 | ZNF44 | HCC2_Meng | Human | Liver | HCC | 7.28e-03 | -7.81e-02 | 0.0107 |
51710 | ZNF44 | HCC2 | Human | Liver | HCC | 4.02e-06 | 2.60e+00 | 0.5341 |
51710 | ZNF44 | HCC5 | Human | Liver | HCC | 3.42e-04 | 9.76e-01 | 0.4932 |
51710 | ZNF44 | male-WTA | Human | Thyroid | PTC | 6.56e-12 | 4.42e-02 | 0.1037 |
51710 | ZNF44 | PTC01 | Human | Thyroid | PTC | 1.86e-12 | 2.30e-01 | 0.1899 |
51710 | ZNF44 | PTC03 | Human | Thyroid | PTC | 1.67e-02 | 1.42e-01 | 0.1784 |
51710 | ZNF44 | PTC04 | Human | Thyroid | PTC | 3.78e-18 | 2.60e-01 | 0.1927 |
51710 | ZNF44 | PTC05 | Human | Thyroid | PTC | 3.22e-21 | 5.79e-01 | 0.2065 |
51710 | ZNF44 | PTC06 | Human | Thyroid | PTC | 1.54e-22 | 4.63e-01 | 0.2057 |
51710 | ZNF44 | PTC07 | Human | Thyroid | PTC | 5.77e-19 | 3.11e-01 | 0.2044 |
51710 | ZNF44 | ATC11 | Human | Thyroid | ATC | 3.39e-02 | 1.97e-01 | 0.3386 |
51710 | ZNF44 | ATC12 | Human | Thyroid | ATC | 3.74e-11 | 1.07e-01 | 0.34 |
51710 | ZNF44 | ATC13 | Human | Thyroid | ATC | 5.11e-10 | 2.10e-01 | 0.34 |
51710 | ZNF44 | ATC2 | Human | Thyroid | ATC | 5.61e-06 | 5.11e-01 | 0.34 |
51710 | ZNF44 | ATC3 | Human | Thyroid | ATC | 1.66e-02 | 2.10e-01 | 0.338 |
51710 | ZNF44 | ATC4 | Human | Thyroid | ATC | 2.54e-14 | 1.40e-01 | 0.34 |
51710 | ZNF44 | ATC5 | Human | Thyroid | ATC | 1.39e-24 | 2.38e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF44 | SNV | Missense_Mutation | rs372299239 | c.602N>A | p.Arg201His | p.R201H | P15621 | protein_coding | tolerated(0.59) | benign(0) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF44 | SNV | Missense_Mutation | c.898N>T | p.Pro300Ser | p.P300S | P15621 | protein_coding | deleterious(0.04) | benign(0.399) | TCGA-E9-A244-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ZNF44 | insertion | Frame_Shift_Ins | novel | c.534_535insTTCTCCATTCACACTGCTTCCACATGCATCTACTCTGG | p.Arg179PhefsTer33 | p.R179Ffs*33 | P15621 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ZNF44 | deletion | In_Frame_Del | c.484_498delGGTCATTCATCCCTG | p.Gly162_Leu166del | p.G162_L166del | P15621 | protein_coding | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |||
ZNF44 | insertion | Frame_Shift_Ins | novel | c.501_502insCA | p.Cys168HisfsTer32 | p.C168Hfs*32 | P15621 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF44 | insertion | Frame_Shift_Ins | novel | c.500_501insAAAAAAAAAAGTTTCCATTTCTT | p.Asn167LysfsTer40 | p.N167Kfs*40 | P15621 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF44 | deletion | Frame_Shift_Del | novel | c.1666delN | p.Ile556PhefsTer12 | p.I556Ffs*12 | P15621 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNF44 | SNV | Missense_Mutation | c.794N>T | p.Arg265Ile | p.R265I | P15621 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF44 | deletion | Frame_Shift_Del | c.766delT | p.Trp256GlyfsTer34 | p.W256Gfs*34 | P15621 | protein_coding | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
ZNF44 | SNV | Missense_Mutation | novel | c.590N>T | p.Gly197Val | p.G197V | P15621 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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