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Gene: ZNF438 |
Gene summary for ZNF438 |
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Gene information | Species | Human | Gene symbol | ZNF438 | Gene ID | 220929 |
Gene name | zinc finger protein 438 | |
Gene Alias | bA330O11.1 | |
Cytomap | 10p11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7Z4V0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
220929 | ZNF438 | NAFLD1 | Human | Liver | NAFLD | 4.66e-05 | 5.41e-01 | -0.04 |
220929 | ZNF438 | HCC1_Meng | Human | Liver | HCC | 3.72e-12 | -4.27e-02 | 0.0246 |
220929 | ZNF438 | HCC2_Meng | Human | Liver | HCC | 8.17e-03 | -2.62e-02 | 0.0107 |
220929 | ZNF438 | S027 | Human | Liver | HCC | 5.39e-03 | 4.67e-01 | 0.2446 |
220929 | ZNF438 | S028 | Human | Liver | HCC | 6.06e-12 | 5.62e-01 | 0.2503 |
220929 | ZNF438 | S029 | Human | Liver | HCC | 1.39e-10 | 5.56e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF438 | SNV | Missense_Mutation | rs35170728 | c.1924G>A | p.Glu642Lys | p.E642K | Q7Z4V0 | protein_coding | deleterious(0.05) | possibly_damaging(0.734) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ZNF438 | SNV | Missense_Mutation | rs764577665 | c.712N>T | p.Gly238Trp | p.G238W | Q7Z4V0 | protein_coding | deleterious(0.02) | possibly_damaging(0.466) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF438 | SNV | Missense_Mutation | c.2116N>C | p.Glu706Gln | p.E706Q | Q7Z4V0 | protein_coding | deleterious(0.02) | possibly_damaging(0.69) | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ZNF438 | SNV | Missense_Mutation | c.215T>C | p.Leu72Pro | p.L72P | Q7Z4V0 | protein_coding | tolerated(1) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF438 | SNV | Missense_Mutation | c.1377N>T | p.Gln459His | p.Q459H | Q7Z4V0 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
ZNF438 | SNV | Missense_Mutation | c.93G>T | p.Lys31Asn | p.K31N | Q7Z4V0 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF438 | SNV | Missense_Mutation | rs773162962 | c.2438C>T | p.Thr813Met | p.T813M | Q7Z4V0 | protein_coding | tolerated(0.13) | benign(0.374) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF438 | SNV | Missense_Mutation | rs773162962 | c.2438N>T | p.Thr813Met | p.T813M | Q7Z4V0 | protein_coding | tolerated(0.13) | benign(0.374) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF438 | SNV | Missense_Mutation | c.1090N>G | p.Pro364Ala | p.P364A | Q7Z4V0 | protein_coding | tolerated(1) | benign(0) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
ZNF438 | SNV | Missense_Mutation | novel | c.2101N>A | p.Trp701Arg | p.W701R | Q7Z4V0 | protein_coding | deleterious(0.04) | benign(0.042) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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